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Diss Factsheets
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EC number: 700-502-6 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- from 2008-08-12 to 2008-08-14
- Reliability:
- 1 (reliable without restriction)
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 009
- Report date:
- 2009
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.2 (Acute Toxicity for Daphnia)
- Deviations:
- no
- Principles of method if other than guideline:
- not applicable
- GLP compliance:
- yes (incl. QA statement)
Test material
Reference
- Name:
- Unnamed
- Type:
- Constituent
- Details on test material:
- not applicable
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material (migrated information):
not applicable
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- at the start and after 48 h at the end of the test
Test solutions
- Vehicle:
- no
- Details on test solutions:
- not applicable
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- Species: Daphnia magna (Straus) not first brood progeny
Age at Test Start: Less than 24 hours old
Sex: Female
Origin: National Institute of Public Health, Hungary
Breeding Conditions:
The Daphnia were bred in the laboratories of LAB Research Ltd. under similar temperature and light conditions as in the test, and in reconstituted water of a similar quality regarding to pH, components of the main ions and total hardness as the test water used in the test. The test animals were fed daily with a few mL of centrifuged algae suspension (Pseudokirchneriella subcapitata).
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 d
- Post exposure observation period:
- not applicable
Test conditions
- Hardness:
- c(CaCO3) of water: 144 mg/L
- Test temperature:
- 19.9 – 20.2 °C
- pH:
- pH 7.79 to 7.89
- Dissolved oxygen:
- 6.3 mg/L or higher
- Salinity:
- not applicable
- Nominal and measured concentrations:
- Concentration Levels in the main test:
Nominal (mg/L): 0.019;0.034;0.070; 0.128; 0.26
Measured at the end of the test (mg/L): 0.008;0.018;0.037; 0.083; 0.24
Mean (mg/L): 0.012; 0.025; 0.051; 0.103; 0.25
The analytically determined mean test item concentrations in the analysed test media varied in the range from 102 % to 119 % at the start and from 52 % to 97 % at the end of the study in comparison to the nominal value. - Details on test conditions:
- not applicable
- Reference substance (positive control):
- no
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 0.012 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- LOEC
- Effect conc.:
- > 0.012 - < 0.03 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- EC0
- Effect conc.:
- 0.012 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 0.03 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: 95 % conf. limits: 0.024 – 0.037
- Duration:
- 48 h
- Dose descriptor:
- EC100
- Effect conc.:
- 0.103 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 24 h
- Dose descriptor:
- EC50
- Effect conc.:
- 0.04 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: 95 % conf. limits: 0.033-0.051
- Details on results:
- not applicable
- Results with reference substance (positive control):
- not applicable
- Reported statistics and error estimates:
- not applicable
Any other information on results incl. tables
no remarks
Applicant's summary and conclusion
- Conclusions:
- In this 48-hour static acute toxicity test to Daphnia magna with F 213 Red the 48 h EC50 value was 0.030 mg/L (Probit analysis), based on measured concentrations. The overall NOEC was determined to be 0.012 mg/L, based on measured concentrations.
- Executive summary:
The analytically determined mean test item concentrations in the analysed test media varied in the range from 102 % to 119 % at the start and from 52 % to 97 % at the end of the study in comparison to the nominal value. The 48h-NOEC (highest concentration tested without toxic effects after the exposure period of 48 hours), respectively the 48h-EC0 of F 213 Red to Daphnia magna was determined to be 0.012 mg test item/L. The 48h-EC50 was calculated to be 0.030 mg test item/L and the 48h-EC100 was determined to be 0.103 mg test item/L.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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