Registration Dossier
Registration Dossier
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EC number: 617-560-2 | CAS number: 84377-83-3
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1-14 July 2016
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- Principles of method if other than guideline:
- Only the preliminary test was carriedout, because the expected water solubility was below the detection limit of the method.
- GLP compliance:
- yes
- Type of method:
- column elution method
- Key result
- Water solubility:
- < 0.3 mg/L
- Conc. based on:
- test mat.
- Temp.:
- 20 °C
- pH:
- 7.16
- Details on results:
- During the preliminary estimation the water solubility of the material was found to be less than 0.3 mg/L. As part of method development a calibration graph was compiled using Acetonitrile as the sample solvent. Solutions of concentration 0 to 0.02168 g/L were prepared for the calibration. The linear range of the calibration was observed to be 0.00108 g/L to 0.02168 g/L. The aqueous solubility of less than 0.3 mg/L is therefore below the detection limit of the analytical method. The water solubility has therefore been reported as < 0.3 mg/L.
- Conclusions:
- Water solubility of the substance is expected to be below 0.3 mg/l.
- Executive summary:
A preliminary water solubility test was carried out on the substance, according to EU Method A.6 and OECD Test Guideline 105.The results found that the water solubility would be below the detection limit of the shake flask method, so it was not possible to carry out the definitive (main) test. The water solubility of the substance at 20C is determined to be < 0.3 mg/l.
Reference
Description of key information
A preliminary water solubility test was carried out on the substance, according to EU Method A.6 and OECD Test Guideline 105.The results found that the water solubility would be below the detection limit of the shake flask method, so it was not possible to carry out the definitive (main) test. The water solubility of the substance at 20C is determined to be < 0.3 mg/l.
Key value for chemical safety assessment
- Water solubility:
- 0.3 mg/L
- at the temperature of:
- 20 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
