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EC number: 271-240-3 | CAS number: 68526-92-1 A complex combination of hydrocarbons produced by the distillation of products from the hydrogenation of isotridecanal from the hydroformylation of dodecene. It consists predominantly of C10-12 olefins and paraffins and C13 alcohols and aldehydes and boils in the range of approximately 160°C to 253°C (320°F to 487°F).
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicological Summary
- Administrative data
- Workers - Hazard via inhalation route
- Workers - Hazard via dermal route
- Workers - Hazard for the eyes
- Additional information - workers
- General Population - Hazard via inhalation route
- General Population - Hazard via dermal route
- General Population - Hazard via oral route
- General Population - Hazard for the eyes
- Additional information - General Population
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.41 mg/m³
- Most sensitive endpoint:
- acute toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- other: ECETOC guidance (Technical Report No. 110, October 2010)
- Overall assessment factor (AF):
- 4 320
- Modified dose descriptor starting point:
- LOAEC
- Value:
- 1 763 mg/m³
- Explanation for the modification of the dose descriptor starting point:
- according to ECHA and ECETOC guidelines; there is no evidence that route-to-route extrapolation cannot be applied.
- AF for dose response relationship:
- 8
- Justification:
- LOAEL based on clinical signs observed in an acute oral toxicity study
- AF for differences in duration of exposure:
- 18
- Justification:
- assuming chronic exposure of the worker
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- no correction for caloric demand for inhalation
- AF for other interspecies differences:
- 1
- Justification:
- according to ECETOC guideline
- AF for intraspecies differences:
- 3
- Justification:
- according to ECETOC guideline
- AF for the quality of the whole database:
- 10
- Justification:
- acute studies available only
- AF for remaining uncertainties:
- 1
- Justification:
- no remaining uncertainties
Acute/short term exposure
- Hazard assessment conclusion:
- hazard unknown (no further information necessary)
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- hazard unknown (no further information necessary)
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.12 mg/kg bw/day
- Most sensitive endpoint:
- acute toxicity
- Route of original study:
- Dermal
DNEL related information
- DNEL derivation method:
- other: ECETOC guidance (Technical Report No. 110, October 2010)
- Overall assessment factor (AF):
- 17 280
- Modified dose descriptor starting point:
- LOAEL
- Value:
- 2 000 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
- not needed, as dermal study is starting point.
- AF for dose response relationship:
- 8
- Justification:
- LOAEL based on clinical signs observed in an acute dermal toxicity study
- AF for differences in duration of exposure:
- 18
- Justification:
- assuming chronic exposure of the worker
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- rat to human
- AF for other interspecies differences:
- 1
- Justification:
- according to guideline
- AF for intraspecies differences:
- 3
- Justification:
- according to guideline
- AF for the quality of the whole database:
- 10
- Justification:
- acute studies available only
- AF for remaining uncertainties:
- 1
- Justification:
- no remaining uncertainties
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 2.22 mg/cm²
- Most sensitive endpoint:
- acute toxicity
DNEL related information
- DNEL derivation method:
- other: ECETOC guidance (Technical Report No. 110, October 2010)
- Overall assessment factor (AF):
- 9
- Dose descriptor:
- other: LOAEL
- AF for dose response relationship:
- 3
- Justification:
- extrapolation LOAEL to NOAEL
- AF for differences in duration of exposure:
- 1
- Justification:
- local effect
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- local effect
- AF for other interspecies differences:
- 1
- Justification:
- according to guideline
- AF for intraspecies differences:
- 3
- Justification:
- difference in sensitivity among workers
- AF for the quality of the whole database:
- 1
- Justification:
- no additional assessment factor required
- AF for remaining uncertainties:
- 1
- Justification:
- no remaining uncertainties
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 2.22 mg/cm²
- Most sensitive endpoint:
- acute toxicity
DNEL related information
- DNEL derivation method:
- other: ECETOC guidance (Technical Report No. 110, October 2010)
- Overall assessment factor (AF):
- 9
- Dose descriptor starting point:
- other: LOAEL
- AF for dose response relationship:
- 3
- Justification:
- extrapolation LOAEL to NOAEL
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- local effect
- AF for other interspecies differences:
- 1
- Justification:
- local effect
- AF for intraspecies differences:
- 3
- Justification:
- difference in sensitivity among workers
- AF for the quality of the whole database:
- 1
- Justification:
- no additional assessment factor required
- AF for remaining uncertainties:
- 1
- Justification:
- no remaining uncertainties
Workers - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - workers
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.12 mg/m³
- Most sensitive endpoint:
- acute toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- other: ECETOC guidance (Technical Report No. 110, October 2010)
- Overall assessment factor (AF):
- 7 200
- Modified dose descriptor starting point:
- LOAEC
- Value:
- 869 mg/m³
- Explanation for the modification of the dose descriptor starting point:
- according to ECHA and ECETOC guidelines; there is no evidence that route-to-route extrapolation cannot be applied.
- AF for dose response relationship:
- 8
- Justification:
- LOAEL based on clinical signs observed in an acute oral toxicity study
- AF for differences in duration of exposure:
- 18
- Justification:
- assuming chronic exposure of the general population
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- no correction for caloric demand for inhalation
- AF for other interspecies differences:
- 1
- Justification:
- according to ECETOC guideline
- AF for intraspecies differences:
- 5
- Justification:
- according to ECETOC guideline
- AF for the quality of the whole database:
- 10
- Justification:
- acute studies available only
- AF for remaining uncertainties:
- 1
- Justification:
- no remaining uncertainties
Acute/short term exposure
- Hazard assessment conclusion:
- hazard unknown (no further information necessary)
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- hazard unknown (no further information necessary)
Acute/short term exposure
- Hazard assessment conclusion:
- hazard unknown (no further information necessary)
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.07 mg/kg bw/day
- Most sensitive endpoint:
- acute toxicity
- Route of original study:
- Dermal
DNEL related information
- DNEL derivation method:
- other: ECETOC guidance (Technical Report No. 110, October 2010)
- Overall assessment factor (AF):
- 28 800
- Modified dose descriptor starting point:
- LOAEL
- Value:
- 2 000 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
- not needed, as dermal study is starting point.
- AF for dose response relationship:
- 8
- Justification:
- LOAEL based on clinical signs observed in an acute dermal toxicity study
- AF for differences in duration of exposure:
- 18
- Justification:
- assuming chronic exposure of the general population
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- rat to human
- AF for other interspecies differences:
- 1
- Justification:
- according to ECETOC guideline
- AF for intraspecies differences:
- 5
- Justification:
- according to ECETOC guideline
- AF for the quality of the whole database:
- 10
- Justification:
- acute studies available only
- AF for remaining uncertainties:
- 1
- Justification:
- no remaining uncertainties
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 1.3 mg/cm²
- Most sensitive endpoint:
- acute toxicity
DNEL related information
- DNEL derivation method:
- other: ECETOC guidance (Technical Report No. 110, October 2010)
- Overall assessment factor (AF):
- 15
- Dose descriptor:
- other: LOAEL
- AF for dose response relationship:
- 3
- Justification:
- extrapolation from LOAEL to NOAEL
- AF for differences in duration of exposure:
- 1
- Justification:
- local effect, according to ECETOC guideline
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- local effect, according to ECETOC guideline
- AF for other interspecies differences:
- 1
- Justification:
- no additional assessment factor required
- AF for intraspecies differences:
- 5
- Justification:
- according to ECETOC guideline
- AF for the quality of the whole database:
- 1
- Justification:
- no additional assessment factor required
- AF for remaining uncertainties:
- 1
- Justification:
- no remaining uncertainties
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 1.3 mg/cm²
- Most sensitive endpoint:
- acute toxicity
DNEL related information
- DNEL derivation method:
- other: ECETOC guidance (Technical Report No. 110, October 2010)
- Overall assessment factor (AF):
- 15
- Dose descriptor starting point:
- other: LOAEL
- AF for dose response relationship:
- 3
- Justification:
- extrapolation from LOAEL to NOAEL
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- local effect, according to ECETOC guideline
- AF for other interspecies differences:
- 1
- Justification:
- no additional assessment factor required
- AF for intraspecies differences:
- 5
- Justification:
- according to ECETOC guideline
- AF for the quality of the whole database:
- 1
- Justification:
- no additional assessment factor required
- AF for remaining uncertainties:
- 1
- Justification:
- no remaining uncertainties
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.07 mg/kg bw/day
- Most sensitive endpoint:
- acute toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- other: ECETOC guidance (Technical Report No. 110, October 2010)
- Overall assessment factor (AF):
- 28 800
- Modified dose descriptor starting point:
- LOAEL
- Value:
- 2 000 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
- not applicable, as starting point is oral toxicity study.
- AF for dose response relationship:
- 8
- Justification:
- LOAEL based on clinical signs observed in an acute dermal toxicity study
- AF for differences in duration of exposure:
- 18
- Justification:
- assuming chronic exposure of the general population
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- rat to human
- AF for other interspecies differences:
- 1
- Justification:
- according to ECETOC guideline
- AF for intraspecies differences:
- 5
- Justification:
- according to ECETOC guideline
- AF for the quality of the whole database:
- 10
- Justification:
- Acute studies available only
- AF for remaining uncertainties:
- 1
- Justification:
- no remaining uncertainties
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - General Population
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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