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EC number: 237-574-9 | CAS number: 13845-36-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Testing was conducted between 23 October 2009 and 12 June 2010.
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- UK GLP standards (Schedule 1, Good Laboratory Practice Regulations 1999 (SI 1999/3106 as amended by SI 2004/0994)). These Regulations are in accordance with GLP standards published as OECD Principles on Good Laboratory Practice (revised 1997, ENV/MC/CHEM
- Type of method:
- flask method
- Water solubility:
- 45.7 other: % w/w
- Temp.:
- 20 °C
- pH:
- 9.1
- Remarks on result:
- other: The solubility of the test material was considered to be independent of both pH and temperature.
- Details on results:
- Please see "Any other information on results" section as these are mostly tables.
- Conclusions:
- Interpretation of results (migrated information): very soluble (> 10000 mg/L)
The ion chromatography method applied directly quantified the dissolved triphosphate content of each sample solution and these have been corrected to equivalent test material concentrations based on the theoretical triphosphate content of the test material. The water solubility of the test material has been determined to be 45.7% w/w of solution at 20.0 ± 0.5°C in un-buffered glass double-distilled water, resulting in a sample solution pH of 9.1.
Investigation into the influence of the pH range 4 to 9 on the solubility of the test material was performed but in each case the test material demonstrated moderately basic characteristics and a significant buffering effect on dissolution, overwhelming the capacity of the buffer solutions to give solution pH’s and solubility results approximately equal to those observed in un-buffered water. Therefore, as the buffering capacity of the solutions used were considered to exceed that of the environment, the solubility of the test material was considered to be independent of the initial pH range 4 to 9, resulting in a consistent basic pH solution capable of overwhelming any weak to moderate buffering capacities present.
The temperature range of 10°C to 30°C was also shown not to have a significant influence on the water solubility of the test material (range 41.7 to 46.0% w/w).
This study is conducted according to an appropriate guideline and under the conditions of GLP and therefore the study is considered to be acceptable and to adequately satisfy both the guideline requirement and the regulatory requirement as a key study for this endpoint. - Executive summary:
Summary
The water solubilty testing was performed using a flask method based on Method A6 Water Solubility of Commission Regulation (EC) No 440/2008 of 30 May 2008. The ion chromatography method applied directly quantified the dissolved triphosphate content of each sample solution and these have been corrected to equivalent test material concentrations based on the theoretical triphosphate content of the test material.The water solubility of the test material has been determined to be 45.7% w/w of solution at 20.0 ± 0.5°C in un-buffered glass double-distilled water, resulting in a sample solution pH of 9.1.
Investigation into the influence of the pH range 4 to 9 on the solubility of the test material was performed but in each case the test material demonstrated moderately basic characteristics and a significant buffering effect on dissolution, overwhelming the capacity of the buffer solutions to give solution pH’s and solubility results approximately equal to those observed in un-buffered water. Therefore, as the buffering capacity of the solutions used were considered to exceed that of the environment, the solubility of the test material was considered to be independent of the initial pH range 4 to 9, resulting in a consistent basic pH solution capable of overwhelming any weak to moderate buffering capacities present.
The temperature range of 10°C to 30°C was also shown not to have a significant influence on the water solubility of the test material (range 41.7 to 46.0% w/w).
Reference
Results
Preliminary testing (Visual assessment)
The sample concentrations and observations recorded on completion of trhe 24 hour equilibration period are shown in the following table:
Observations after Equilibration at 30°C
Sample |
Concentration |
Observations |
1 |
30.1 |
A hazy solution containing excess, un-dissolved test material at the base of the vessel. |
2 |
40.0 |
A hazy solution containing excess, un-dissolved test material at the base of the vessel. |
3 |
50.0 |
A hazy solution containing excess, un-dissolved test material at the base of the vessel. |
4 |
59.9 |
A hazy solution containing excess, un-dissolved test material at the base of the vessel. |
5 |
69.9 |
No visible solution, with all water absorbed to give a block of solid test material. |
The solution pH’s on completion of the preliminary test are shown in the following table:
Sample |
Concentration |
Solution pH |
1 |
30.1 |
9.4 |
2 |
40.0 |
9.6 |
3 |
50.0 |
9.8 |
4 |
59.9 |
10.1 |
5 |
69.9 |
10.4 |
Preliminary
test result: Solubility at 30.0°C: Less than 30.1% w/w (by visual
assessment)
Preliminary testing (with ion chromatography analysis)
Un-buffered glass double-distilled water
The preliminary estimate of water solubility, as equivalent test material concentration, was 269 g/l, with a final sample solution pH of 9.3.
pH 4 buffer solution
The preliminary estimate of water solubility, as equivalent test material concentration, was 255 g/l, with a final sample solution pH of 9.2.
pH 9 buffer solution
The preliminary estimate of water solubility, as equivalent test material concentration, was 262 g/l, with a final sample solution pH of 9.3.
Definitive test
The mean triphosphate peak areas relating to the standard and sample solutions are shown in the following table:
Solution |
Area |
Standard 22.2 mg/l |
2.015 |
Standard 20.3 mg/l |
1.882 |
Matrix blank |
none detected |
Sample 1A |
3.146 |
Sample 1B |
3.093 |
Sample 2A |
3.133 |
Sample 2B |
3.164 |
Sample 3A |
3.095 |
Sample 3B |
3.122 |
Sample 4A |
3.146 |
Sample 4B |
3.144 |
Sample 5A |
2.718 |
Sample 5B |
2.758 |
The equivalent concentration (g/l) of test material in the sample solutions is shown in the following table:
Sample |
Time Shaken at ~ 30ºC (hours) |
Equilibration Temperature (°C) |
Equilibration Time (hours) |
Equivalent Test Material Concentration |
Solution pH |
1 |
24 |
20 |
24 |
45.5 |
9.1 |
2 |
48 |
20 |
24 |
46.3 |
9.1 |
3 |
72 |
20 |
24 |
45.3 |
9.1 |
4 |
72 |
30 |
24 |
46.0 |
9.1 |
5 |
72 |
10 |
24 |
41.7 |
9.0 |
Mean
concentration:45.7% w/w at 20.0 ± 0.5ºC (samples 1 to 3 inclusive only)
Range: 45.3 to 46.3% w/w (samples 1 to
3 inclusive only)
Validation
The linearity of the detector response with respect to concentration was assessed over the nominal standard concentration range of 0 to 75 mg/l, equivalent to approximately 0 to 44 mg/l as the triphosphate anion. This was satisfactory with a correlation coefficient of 1.000 being obtained.
Description of key information
The water solubility was determined according to EU Method A.6 (Water solubility) and under the conditions of GLP.
Key value for chemical safety assessment
Additional information
The ion chromatography method applied directly quantified the dissolved triphosphate content of each sample solution and these have been corrected to equivalent test material concentrations based on the theoretical triphosphate content of the test material. The water solubility of the test material has been determined to be 45.7% w/w of solution at 20.0 ± 0.5°C in un-buffered glass double-distilled water, resulting in a sample solution pH of 9.1.
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