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EC number: 215-559-8 | CAS number: 1331-61-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The counter ion (ammonium) is not conisdered a potential irritant at low concentrations under neutral conditions, so the assessment is based on other salts.
Two GLP, Guideline in vitro tests were performed in order to assess the skin corrosive/irritating potential of LAS IPA salt and these are considered directly comparable to the ammonium salt. The results show that the substance is not corrosive to the skin, but it does have irritating properties. This is further supported by two older in vivo tests with benzenesulfonic acid, dodecyl-, branched, compd. with 2-propanamine. One GLP in vitro eye irritation test suggests that the substance is irritating to the eye. However, this test is not sofar officially accepted for regulatory purposes, and hence, additional information was used from an older sin vivo study performed with benzenesulfonic acid, dodecyl-, branched, compound. with 2-propanamine. The study suggest that the substance is an eye irritant.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin irritation
The potential skin effects of benzenesulfonic acid, 4-C10-13-sec-alkyl derivs.-, compd. with 2-propanamine (97%) were tested in two in vitro studies with the use of reconstructed human epidermis models (EPISKINTM). The principle of the assays is based on the measurement of cytotoxicity in the human epidermal cultures following topical exposure to the test material, with the MTT reduction assay. The in vitro test for skin corrosion gave a negative result, while the in vitro test for skin irritation suggests that the substance has skin irritating properties. Additional supporting information taken from two in vivo studies performed with benzenesulfonic acid, dodecyl-, branched, compd. with 2-propanamine suggest that LAS IPA is an irritant to the skin of the rabbit.
Eye irritation
An in vitro eye irritation test was performed with the use of the SkinEthic Human Corneal Epithelium model in order to examine the eye irritation potential of benzenesulfonic acid, 4-C10-13-sec-alkyl derivs.-, compd. with 2-propanamine (97%). The results showed a relative mean viability of the test item treated tissues after a 10 min exposure period of 16.6 %, i.e. the test the test item shall be considered an eye irritant. Nonetheless, currently, the aforementioned test is not fully validated on a regulatory context. Therefore, the classification of the test item cannot be based solely on this test. In an additional in vivo test performed with benzenesulfonic acid, dodecyl-, branched, compd. with 2-propanamine, eye irritation was also observed. Taken together, LAS IPA shall be classified and labelled as irritating to the eye.
Justification for selection of skin irritation / corrosion endpoint:
The weight of evidence approach was applied to address the endpoint of skin irritation, since no study available can per se address this requirement; information from four available studies were used.
Justification for selection of eye irritation endpoint:
The weight of evidence approach was applied to address the endpoint of skin irritation, since no study available can per se address this requirement; information from two available studies were used.
Effects on skin irritation/corrosion: irritating
Effects on eye irritation: irritating
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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