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Diss Factsheets
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EC number: 213-928-8 | CAS number: 1067-33-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
In accordance with column 2 of REACH annex VIII, it is considered justifiable to omit the acute toxicity studies as the substance is classified as corrosive to the skin.
The following supporting studies were available for the acute toxicity: oral endpoint:
Schafer E. W. & Bowles A. W. (1985). Acute Oral Toxicity and Repellency of 933 Chemicals to House and Deer Mice. Arch. Environ. Contam. Toxicol. 14: 111-129. Testing laboratory: U. S. Department of Interior - Fish and Wildlife Service, Denver Wildlife Research Center, Building 16 - Denver Federal Center, Denver, Colorado 80225.
Result: An approximate lethal dose of dibutyltin diacetate in deer mice was determined to be 1070 mg/kg. A second toxicity test determined the LD50 of dibutyltin diacetate of >87.5 mg/kg/day.
Acros Organics (2007). Material Safety Data Sheet. Dibutyltin diacetate pract. website https: //fscimage. fishersci. com/msds/75959. htm. Owner company: Acros Organics N. V., One Reagent Lane, Fair Lawn, NJ 07410. Study number: ACC# 75959. Report date: 2007-03-16.
Result: This MSDS reported an LD50 of 46mg/kg for dibutyltin diacetate for mouse and an LD50 of 32mg/kg for rat. According to the MSDS, dibutyltin diacetate is classified as 'Toxic if Swallowed'.
Key value for chemical safety assessment
Additional information
Although data were available concerning acute toxicity via the oral route, the data is not adequate to accurately assign a classification. The material safety data sheet from Arcos Organics (2007) as a secondary source cannot be assessed for reliability, further to this, the safety data sheet does not reference the data sources. The available literature study, Schafer & Bowles (1985), although performed in line with good scientific principles, the study is not performed in the preferred species, and the data available is not sufficient to assess the acute toxicity of dibutyltin di(acetate).
Justification for classification or non-classification
From the data available, it is not possible to accurately assign a classification. From the results of the presented in vitro skin corrosion study (Warren, 2010), dibutyltin di(acetate) is considered corrosive, and any further testing is waived on ethical grounds.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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