Registration Dossier
Registration Dossier
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EC number: 211-067-2 | CAS number: 629-03-8
Bioaccumulation: aquatic / sediment
Administrative data
- Endpoint:
- bioaccumulation: aquatic / sediment
- Type of information:
- calculation (if not (Q)SAR)
- Remarks:
- Migrated phrase: estimated by calculation
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data collected from modelling - US EPA Tool - BCFBAF v.3.01
Data source
Reference
- Reference Type:
- other: Modelling - EpiSuite v4.1 - US EPA Tool - BCFBAF v.3.01
- Title:
- Unnamed
- Report date:
- 2012
Materials and methods
- Principles of method if other than guideline:
- EPI Suite™ is a screening-level predictive tool based on SMILE notation. The estimation methods in EPI Suite™ have been developed by government, academic, and private sector researchers over many years and represent some of the best techniques currently available. Moreover, the intended application domain of EPI Suite is organic chemicals which is in line with the test item.
Results and discussion
Bioaccumulation factoropen allclose all
- Type:
- BCF
- Value:
- 194.9 L/kg
- Basis:
- whole body w.w.
- Calculation basis:
- steady state
- Remarks:
- Modelling - BCFBAF V3.01 - US EPA tool - Estimation methodology
- Remarks on result:
- other: Log BCF = 2.290
- Type:
- BCF
- Value:
- 192.4 L/kg
- Basis:
- whole body w.w.
- Calculation basis:
- other: Modelling - BCFBAF V3.01 - US EPA tool - Estimation methodology
- Remarks on result:
- other: Arnot-Gobas modelling including biotransformation rate estimates for upper trophic level.
- Type:
- BAF
- Value:
- 192.5 L/kg
- Calculation basis:
- steady state
- Remarks:
- Modelling - BCFBAF V3.01 - US EPA tool - Estimation methodology
- Remarks on result:
- other: Arnot-Gobas modelling including biotransformation rate estimates for upper trophic level.
- Type:
- BCF
- Value:
- 217.2 L/kg
- Basis:
- whole body w.w.
- Calculation basis:
- steady state
- Remarks:
- Modelling - BCFBAF V3.01 - US EPA tool - Estimation methodology
- Remarks on result:
- other: Arnot-Gobas modelling including biotransformation rate estimates for mid trophic level.
- Type:
- BAF
- Value:
- 218 L/kg
- Basis:
- whole body w.w.
- Calculation basis:
- steady state
- Remarks:
- Modelling - BCFBAF V3.01 - US EPA tool - Estimation methodology
- Remarks on result:
- other: Arnot-Gobas modelling including biotransformation rate estimates for mid trophic level.
- Type:
- BCF
- Value:
- 220.1 L/kg
- Basis:
- whole body w.w.
- Calculation basis:
- steady state
- Remarks:
- Modelling - BCFBAF V3.01 - US EPA tool - Estimation methodology
- Remarks on result:
- other: Arnot-Gobas modelling including biotransformation rate estimates for lower trophic level.
- Type:
- BAF
- Value:
- 224.7 L/kg
- Basis:
- whole body w.w.
- Calculation basis:
- steady state
- Remarks:
- Modelling - BCFBAF V3.01 - US EPA tool - Estimation methodology
- Remarks on result:
- other: Arnot-Gobas modelling including biotransformation rate estimates for lower trophic level.
- Type:
- BCF
- Value:
- 2 990 L/kg
- Basis:
- whole body w.w.
- Calculation basis:
- steady state
- Remarks:
- Modelling - BCFBAF V3.01 - US EPA tool - Estimation methodology
- Remarks on result:
- other: Arnot-Gobas modelling assuming a biotransformation rate of zero for upper trophic level.
- Type:
- BAF
- Value:
- 3 335 L/kg
- Basis:
- whole body w.w.
- Calculation basis:
- steady state
- Remarks:
- Modelling - BCFBAF V3.01 - US EPA tool - Estimation methodology
- Remarks on result:
- other: Arnot-Gobas modelling assuming a biotransformation rate of zero for upper trophic level.
Applicant's summary and conclusion
- Conclusions:
- No testing is currently available to assess the bioaccumation in living organisms. However, the log Kow estimate (logKow = 3.8) indicates that the substance may bioaccumulate to a significant degree (Guidance on information requirements, ECHA, Chapter R7c, pp23). Nevertheless, when running modelisation (BCFBAF v3.01 - US EPA tool), it seems that the registered substance does not bioaccumate into organisms when the biotransformation rate in fish is considered. However, no further details are currently available on the registered substance metabolization.
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