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EC number: 205-465-5 | CAS number: 141-17-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 22 Sept - 20 Oct 1992
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Remarks:
- Analytical purity not stated.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 B (Ready Biodegradability: CO2 Evolution Test)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- The Department of Health of the Government of the United Kingdom
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic, non-adapted
- Details on inoculum:
- - Source of inoculum/activated sludge: Activated sludge was collected from the aeration stage of the Severn Trent Plc sewage treatment plant at Belper, Derbyshire, which treats predominantly domestic sewage. (date of collection: 22 Sept 1992)
- Pretreatment: The activated sludge was homogenized for 10 min. The solids were then removed by centrifuging and the supernatant was taken for testing. - Duration of test (contact time):
- 28 d
- Initial conc.:
- 10 mg/L
- Based on:
- test mat.
- Initial conc.:
- 20 mg/L
- Based on:
- test mat.
- Parameter followed for biodegradation estimation:
- CO2 evolution
- Details on study design:
- TEST CONDITIONS
- Composition of medium: Solution 1: FeCl3x6H2O = 0.25 g/L; Solution 2: MgSO4x7H2O = 22.5 g/L; Solution 3: CaCl2 = 27.5 g/L; Solution 4: (NH4)2SO4 = 40 g/L; Solution 5: KH2PO4 = 8.5 g/L, K2HPO4 = 27.75 g/L, Na2HPO4x7H2O = 33.4 g/L, NH4Cl = 1.7 g/L
4 mL Solution 1, 1 mL of each Solution 2, 3 and 4 and 2 mL Solution 5 were added to 1 L of purified water
- Test temperature: 21 ± 1 °C
- pH: day 27: 10 mg/L = 5.4; 20 mg/L = 5.6; control = 5.3; standard = 5.4
- Continuous darkness: yes
TEST SYSTEM
- Culturing apparatus: 5 L glass culture vessel containing 3 L
- Number of culture flasks/concentration: 2 (1 per test substance concentration)
- Method used to create aerobic conditions: The culture vessels were sealed and CO2-free air bubbled through the solution at a rate of ~ 2 bubbles per second and stirred continuously by magnetic stirrers.
- Measuring equipment: Ionics 555 TOC analyser
- Details of trap for CO2 and volatile organics if used: CO2 was absorbed using 2 500 mL Dreschel bottles filled with 350 mL 0.05 M NaOH
SAMPLING
- Sampling frequency: Samples (2 mL, in triplicate) were taken from the first absorber vessel on days 0, 1, 2, 3, 6, 8, 10, 14, 16, 21, 23, 27 and 28. The second absorber vessel was sampled on days 0 and 28.
- Sampling method: On day 27 the pH of each test vessel was measured and 1 mL of concentrated HCl added to drive of inorganic carbonate. The vessels were aerated overnight and the final samples were taken from both absorber vessels on day 28.
CONTROL AND BLANK SYSTEM
- Inoculum blank: 2 (with and without standard) - Reference substance:
- benzoic acid, sodium salt
- Remarks:
- 20 mg/L
- Parameter:
- % degradation (CO2 evolution)
- Value:
- 74
- Sampling time:
- 28 d
- Remarks on result:
- other: 10 mg/L test substance concentration
- Parameter:
- % degradation (CO2 evolution)
- Value:
- 82
- Sampling time:
- 28 d
- Remarks on result:
- other: 20 mg/L test substance concentration
- Details on results:
- The test substance reached biodegradation values of 74 (10 mg/L) and 82% (20 mg/L) after 28 days test duration. Furthermore,
degradation over 60% took place within the 10d-window period. Therefore, the test substance can be considered as readily biodegradable. - Results with reference substance:
- Sodium acetate reached a biodegradation value of 86% at the end of the test. Besides, degradation over 60% occurred within 14 days (79%).
- Validity criteria fulfilled:
- not specified
- Remarks:
- See "Any other information on results incl. tables"
- Interpretation of results:
- readily biodegradable
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 01 Sep 1983 - 20 Jan 1984
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
- Qualifier:
- according to guideline
- Guideline:
- other: Circular on Test Methods of New Chemical Substances (Japan), Biodegradation test
- Deviations:
- no
- GLP compliance:
- not specified
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge (adaptation not specified)
- Duration of test (contact time):
- 14 d
- Initial conc.:
- 100 mg/L
- Based on:
- test mat.
- Parameter followed for biodegradation estimation:
- O2 consumption
- Parameter followed for biodegradation estimation:
- TOC removal
- Parameter followed for biodegradation estimation:
- test mat. analysis
- Remarks:
- by LC
- Details on study design:
- TEST CONDITIONS
- Composition of medium: recomended medium in the guideline
- Test temperature: 25 °C
- Suspended solids concentration: 30 mg/L
TEST SYSTEM
- Culturing apparatus: closed oxygen consumption measuring machine with 300 mL culture bottle
- Number of culture flasks/concentration: 1 (water + test substance), 3 (sludge + test sub.), 1 (sludge + reference sub.), 1 (sludge)
SAMPLING
- Sampling frequency: continuously
- Sterility check if applicable: no
- Sample storage before analysis: no data
CONTROL AND BLANK SYSTEM
- Inoculum blank: yes - Reference substance:
- aniline
- Parameter:
- % degradation (O2 consumption)
- Value:
- 86
- Sampling time:
- 14 d
- Parameter:
- % degradation (TOC removal)
- Value:
- 98
- Sampling time:
- 14 d
- Parameter:
- % degradation (test mat. analysis)
- Value:
- 100
- Sampling time:
- 14 d
- Details on results:
- see table 1
- Results with reference substance:
- BOD of aniline was 62% at day 7.
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- readily biodegradable
Referenceopen allclose all
Table 1. Results of BOD
|
day 7 |
day 14 |
BOD [mg]
|
BOD [mg] |
|
Sludge + Test sub. |
27.8 |
58.0 |
Sludge + Test sub. |
28.3 |
59.5 |
Sludge + Test sub. |
32.0 |
60.3 |
Water + Test sub. |
0 |
0 |
Control blank |
4.5 |
5.3 |
Sludge + Aniline |
61.0 |
73.0 |
Description of key information
Readily biodegradable: 74 - 82% in 28 days (CO2 evolution, OECD 301B)
Key value for chemical safety assessment
- Biodegradation in water:
- readily biodegradable
- Type of water:
- freshwater
Additional information
Two studies investigating the ready biodegradability of Bis(2-(2-butoxyethoxy)ethyl) adipate (CAS No. 141-17-3) are available. The key study was conducted according to OECD 301B under GLP conditions using non-adapted activated sludge as inoculum. Mean degradation of 74 (10 mg test material/L) and 82% (20 mg test material/L) were observed after 28 days. The 10-day-window was met. Hence, the test substance is determined to be readily biodegradable according to OECD criteria. This conclusion is supported by an additional study on aerobic degradation conducted by Japanese authorities according to the “Circular on test methods of new chemical substances, biodegradation test”. In this study the test substance reached a biodegradation of 86% within 14 days.
Hence, Bis(2-(2-butoxyethoxy)ethyl) adipate can be considered readily biodegradable according to OECD criteria.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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