Registration Dossier
Registration Dossier
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EC number: 204-062-1 | CAS number: 115-07-1
Toxicological Summary
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
Workers - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - workers
A DNEL for acute toxicity should be derived if an acute hazard leading to acute toxicity (e.g. C&L) has been identified and there is a potential for high peak exposures. This is not the case with propene.
Systemic effects: None at the highest dose level tested in chronic toxicity study.
Local effects: The weight of evidence indicates that the nasal effects in rodents, which unlike man are obligate nasal breathers, superimposed on a high background of spontaneous nasal pathology and with no obvious dose-response relationships, are likely to be of little relevance in extrapolation of risk to humans and considered an inappropriate finding from which to derive a DNEL. In addition, the concentrations at which these effects were reported in the animal experiments are very high compared to the actual human exposure levels in practice.
Dermal and oral studies with propene are not technically feasible as the substance is a gas at room temperature.
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - General Population
A DNEL for acute toxicity should be derived if an acute hazard leading to acute toxicity (e.g. C&L) has been identified and there is a potential for high peak exposures. This is not the case with propene.
Systemic effects: None at the highest dose level tested in chronic toxicity study.
Local effects: The weight of evidence indicates that the nasal effects in rodents, which unlike man are obligate nasal breathers, superimposed on a high background of spontaneous nasal pathology and with no obvious dose-response relationships, are likely to be of little relevance in extrapolation of risk to humans and considered an inappropriate finding from which to derive a DNEL. In addition, the concentrations at which these effects were reported in the animal experiments are very high compared to the actual human exposure levels in practice.
Dermal and oral studies with propene are not technically feasible as the substance is a gas at room temperature.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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