Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 202-852-0 | CAS number: 100-43-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Effect on fertility: via oral route
- Endpoint conclusion:
- no adverse effect observed
- Quality of whole database:
- adequate
Effect on fertility: via inhalation route
- Endpoint conclusion:
- no study available
Effect on fertility: via dermal route
- Endpoint conclusion:
- no study available
Additional information
The substance has been studied in a validated QSAR and found to be inactive for reproductive toxicity, or not a reproductive toxicant. When a structural analogue (2 -vinylpyridine) is studied in a 90-day repeated dose toxicity study, there is no evidence of toxicity to reproductive organs at doses causing systemic toxicity.
Short description of key information:
Review of the toxicity of reproductive organs in rats after subchronic exposure to a structural analogue, 2-vinylpyridine, the substance does not selectively target the reproductive organs. The substance is predicted by a validated QSAR to be inactive for reproductive toxicity, or "nonthreatening" to humans.
Justification for selection of Effect on fertility via oral route:
Valid QSAR model
Effects on developmental toxicity
Description of key information
A validated QSAR predicts 4-vinylpyridine to be "inactive" for developmental toxicity, or a "non developmental toxin".
Effect on developmental toxicity: via oral route
- Endpoint conclusion:
- no adverse effect observed
- Quality of whole database:
- adequate
Effect on developmental toxicity: via inhalation route
- Endpoint conclusion:
- no study available
Effect on developmental toxicity: via dermal route
- Endpoint conclusion:
- no study available
Additional information
Risk assessment for teratogenicity is performed qualitatively, based on a categorical structure-activity relationship (SAR). Using a validated SAR model of teratogenicity in humans based on 323 chemical substances, 4VP was predicted to be "inactive" or "not teratogenic".
Justification for selection of Effect on developmental toxicity: via oral route:
Validated (Q)SAR model
Justification for classification or non-classification
Existing in vivo studies of rats exposed to a structural analogue, 2-vinylpyridine, have been reviewed to ascertain the potential for reproductive toxicity. There is no evidence of toxicity to reproductive organs at doses causing systemic toxicity.
Concerning developmental toxicity, a structure-activity model predicts that 4-VP is inactive (not a developmental toxin, non-teratogenic).Therefore, 4-VP is not considered to be a reproductive or developmental toxicant. Further testing is not appropriate, as this substance is corrosive at the site of contact. This is discouraged in Annex VIII and Annex IX introductions, where "in vivo testing with corrosive substances at concentration/dose levels causing corrosivity shall be avoided".
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.