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EC number: 236-144-8 | CAS number: 13189-00-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 22 May - 10 June 2012
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Justification for type of information:
- No justification could be found in the records.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 013
- Report date:
- 2013
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- Principles of method if other than guideline:
- Not applicable
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Zinc methacrylate
- EC Number:
- 236-144-8
- EC Name:
- Zinc methacrylate
- Cas Number:
- 13189-00-9
- Molecular formula:
- C4H6O2.1/2Zn
- IUPAC Name:
- zinc methacrylate
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- - Name of test material (as cited in study report): Zinc Dimethacrylate
- Physical state: White powder
- Analytical purity: 95.3 %
- Lot/batch No.: 1107289741
- Date of receipt: 10 April 2012
- Expiration date of the lot/batch: 31 October 2012
- Storage condition of test material: Room temperature in the dark over silica gel
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Harlan Laboratories UK Ltd., Leicestershire, UK.
- Age at study initiation: 12-20 weeks
- Weight at study initiation: 2.59-2.64 kg
- Housing: Animals were individually housed in suspended cages.
- Diet: Food (2930C Teklad Global Rabbit diet supplied by Harlan Laboratories UK Ltd., Oxon, UK), ad libitum
- Water: Mains drinking water, ad libitum
- Acclimation period: 5 days
ENVIRONMENTAL CONDITIONS
- Temperature: 17-23 °C
- Humidity: 30-70 %
- Air changes: 15 changes/h
- Photoperiod: 12 h dark / 12 h light
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- other: clipped
- Vehicle:
- other: 0.5 g of the test item, moistened sufficiently with 0.5 ml of distilled water to achieve paste consistency
- Controls:
- not required
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (weight with unit): 0.5 g - Duration of treatment / exposure:
- 4 h
- Observation period:
- 7 days for first animal and 72 h for remaining two animals.
- Number of animals:
- 3 males
- Details on study design:
- TEST SITE
- Area of exposure: Dorsal/flank area
- Type of wrap if used: Test item was applied to the skin under a 2.5 cm x 2.5 cm cotton gauze patch. The patch was secured in position with a strip of surgical adhesive tape. To prevent the animal interfering with the patch, the trunk of the rabbit was wrapped in an elasticated corset and the animal was returned to its cage for the duration of the 4 hour exposure period.
REMOVAL OF TEST SUBSTANCE
- After removal of the dressing, any residual test item removed by gentle swabbing with cotton wool soaked in distilled water.
- Time after start of exposure: 4 h
SCORING SYSTEM: According to OECD Guideline 404
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Remarks:
- mean individual score
- Time point:
- 24/48/72 h
- Score:
- ca. 2
- Max. score:
- 4
- Reversibility:
- fully reversible within: 7 days
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Remarks:
- mean individual score
- Time point:
- 24/48/72 h
- Score:
- ca. 1.3
- Max. score:
- 4
- Reversibility:
- fully reversible within: 7 days
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Remarks:
- mean individual score
- Time point:
- 24/48/72 h
- Score:
- ca. 0
- Max. score:
- 4
- Reversibility:
- other: not applicable
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Remarks:
- mean individual score
- Time point:
- 24/48/72 h
- Score:
- ca. 0
- Max. score:
- 4
- Reversibility:
- other: not applicable
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Remarks:
- mean individual score
- Time point:
- 24/48/72 h
- Score:
- ca. 0
- Max. score:
- 4
- Reversibility:
- other: not applicable
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Remarks:
- mean individual score
- Time point:
- 24/48/72 h
- Score:
- ca. 0
- Max. score:
- 4
- Reversibility:
- other: not applicable
- Irritant / corrosive response data:
- - Very slight erythema and very slight oedema were noted at one treated skin site immediately after patch removal with well-defined erythema and slight oedema noted at 1 and 24 h after patch removal. Well-defined erythema and very slight oedema were noted at this treated skin site at the 48 and 72 h observations. Light brown discolouration of the epidermis and loss of skin elasticity were noted at this treated skin site at the 24, 48 and 72 h observations with slight desquamation noted at the 7-Day observation.
- No evidence of skin irritation was noted at two treated skin sites during the study. - Other effects:
- All animals showed expected bodyweight gain during the study.
Any other information on results incl. tables
Table 7.3.1/1: Individual Skin Reactions
Skin Reaction |
Observation Time (following patch removal) |
Individual Scores – Rabbit Number and Sex |
||
72042 Male |
72101 Male |
72102 Male |
||
Erythema/Eschar Formation |
Immediately |
1 |
0 |
0 |
1 h |
2 |
0 |
0 |
|
24 h |
2 BrLe |
0 |
0 |
|
48 h |
2 BrLe |
0 |
0 |
|
72 h |
2 BrLe |
0 |
0 |
|
7 days |
0D |
- |
- |
|
Mean (24, 48 and 72 h) |
2 |
0 |
0 |
|
Oedema Formation |
Immediately |
1 |
0 |
0 |
1 h |
2 |
0 |
0 |
|
24 h |
2 |
0 |
0 |
|
48 h |
1 |
0 |
0 |
|
72 h |
1 |
0 |
0 |
|
7 days |
0 |
- |
- |
|
Mean (24, 48 and 72 h) |
1.3 |
0 |
0 |
Br = Light brown discolouration of the epidermis
Le = Loss of skin elasticity
D = Slight desquamation
- = Not applicable
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Under the test conditions, Zinc Dimethacrylate is not classified as irritating to skin.
- Executive summary:
In a primary dermal irritation study performed according to OECD Guideline 404 and in compliance with GLP, three male New Zealand White rabbits were dermally exposed to 0.5 g of Zinc Dimethacrylate under a semi-occlusive dressing. The test item was first evaluated on a single animal and the duration of exposure was 4 h on the dorsal/flank area. After consideration of the skin reactions produced in the first animal, two additional animals were similarly treated. After removal of the residual test item, irritation was scored as outlined in the OECD Guideline 404 at 1, 24, 48 and 72 h and 7 days after exposure. Very slight erythema and very slight oedema were noted at one treated skin site immediately after patch removal with well-defined erythema and slight oedema noted at 1 and 24 h after patch removal. Well-defined erythema and very slight oedema were noted at this treated skin site at the 48 and 72 h observations. Light brown discolouration of the epidermis and loss of skin elasticity were noted at this treated skin site at the 24, 48 and 72 h observations with slight desquamation noted at the 7-Day observation. No evidence of skin irritation was noted at two treated skin sites during the study. Mean individual scores at 24, 48 and 72 h after exposure for the 3 animals were 2, 0, 0 for erythema and 1.3, 0, 0 for oedema score, respectively. In this study, Zinc Dimethacrylate is not a skin irritant on male rabbits. Under the test conditions, Zinc Dimethacrylate was not classified as irritating to skin (Bradshaw, 2012).
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