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Diss Factsheets
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EC number: 203-678-8 | CAS number: 109-53-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 988
- Report date:
- 1988
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- no
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Isobutyl vinyl ether
- EC Number:
- 203-678-8
- EC Name:
- Isobutyl vinyl ether
- Cas Number:
- 109-53-5
- Molecular formula:
- C6H12O
- IUPAC Name:
- 1-(ethenyloxy)-2-methylpropane
- Details on test material:
- isobutyl vinyl ether (IBVE)
purity > 99.5%
Stability was given during study period
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Mean body weights: 267 and 183 g for male and female rats, respectively
Age: 8 to 9 weeks at start of treatment
Rats received standard diets and water ad libitum
Room temperature was 20-24°C
Relative air humidity 30-70%.
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: air
- Details on inhalation exposure:
- The animals were singly placed into compartments in an inhalation chamber (glass-steel, volume 200 l). Atmosphere was dynamically generated. Air passed an evaporator to which TS was pumped. Vapors were mixed with fresh air. Air was delivered to the inhalation chamber at a rate of 3000 l/h.
- Analytical verification of test atmosphere concentrations:
- yes
- Remarks:
- (the concentration was measured using gas chromatography)
- Duration of exposure:
- 4 h
- Concentrations:
- 21.1 mg/L
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- Post exposure period was 14 days.
The animals were observed for clinical signs of toxicity on working days and daily for mortality for 14 days. Body weights were recorded on days 0, 7, and 14. At the end of the observation period the animals were sacrificed and necropsied. - Statistics:
- Binominal test (Wittig 1974) was used.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC0
- Effect level:
- 21.1 mg/L air (analytical)
- Exp. duration:
- 4 h
- Remarks on result:
- other: clinical signs but no mortality, 14 d observation period
- Mortality:
- no mortality
- Clinical signs:
- other: During exposure: apathia, stagger, depressed breathing, reddened ears and extremities, unkempt fur. After exposure: unsteady gait. No symptoms were noted from the day following exposure.
- Body weight:
- Body weight development was comparable to historical controls but slightly delayed in females.
- Gross pathology:
- No effects detected at necropsy.
- Other findings:
- no
Applicant's summary and conclusion
- Conclusions:
- In an acute inhalation study in rats no mortality was found after 4 h exposure to 21.1 mg/L and a post exposure period of 14 days (the recommended limit dose according to OECD TG403 is 5 mg/L); LC50 (4h) > 21 mg/L.
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