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Diss Factsheets
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EC number: 205-771-9 | CAS number: 150-78-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: dermal
Administrative data
- Endpoint:
- short-term repeated dose toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Not enough details of experimental procedure for an evaluation of the study.
Data source
Reference
- Reference Type:
- publication
- Title:
- Short-term toxicity tests on the mono and di methyl ethers of hydroquinone
- Author:
- Hodge HC, Sterner JH, Maynard EA, Thomas J.
- Year:
- 1 949
- Bibliographic source:
- J. Ind. Hyg. Toxicol. 31, 79-92.
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Subacute toxicity by dermal application
- GLP compliance:
- no
Test material
- Reference substance name:
- 1,4-dimethoxybenzene
- EC Number:
- 205-771-9
- EC Name:
- 1,4-dimethoxybenzene
- Cas Number:
- 150-78-7
- Molecular formula:
- C8H10O2
- IUPAC Name:
- 1,4-dimethoxybenzene
- Details on test material:
- no data
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- no data
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- other: sun tan lotion
- Details on exposure:
- TEST SITE
- Area of exposure: the areas of the skin on the back and sides of the rabbits were prepared by clipping the fur and then applying a depilatory.
- % coverage: no data
- Type of wrap if used: no data
REMOVAL OF TEST SUBSTANCE
- Washing (if done): unwashed
- Time after start of exposure: no data
TEST MATERIAL
- Amount(s) applied: 5 ml of sun tan lotion base prepared on two basic formulae.
One contained the specified amount of PDMB (1g or 10g), 5 g of castor oil, 6 g of water and alcohol to make 100 g.
The other formula contained the specified amount of PDMB (1g or 10g), 15 g of butyl stearate, and alcohol to make 100 g.
- concentration (if solution): 1% or 10%
VEHICLE: sun tan lotion
2 different formulations: One contained the specified amount of PDMB, 5 g of castor oil, 6 g of water and alcohol to make 100 g. The other formula contained the specified amount of PDMB, 15 g of butyl stearate, and alcohol to make 100 g. - Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 30 days
- Frequency of treatment:
- 5 days a week.
Doses / concentrations
- Remarks:
- Doses / Concentrations:
5 ml of solution at 1 and 10% in sun tan lotion
Basis:
other: 2 different formulations
- No. of animals per sex per dose:
- 6 animals per dose group (sex unspecified)
- Control animals:
- other: yes, animals received sun tan lotion preparation
- Details on study design:
- no data
- Positive control:
- no data
Examinations
- Observations and examinations performed and frequency:
- * CAGE SIDE OBSERVATIONS: No data
BODY WEIGHT: Yes
- Time schedule for examinations: weekly
MORTALITY: Yes
- Time schedule for examinations: no mortality during the test
ORGAN WEIGHT: YES (heart, lungs, spleen, liver, kidneys, brain, stomach, testes)
FOOD CONSUMPTION: No data
WATER CONSUMPTION: No data
CLINICAL SIGNS: No data
FUNCTIONAL OBSERVATIONS: No data
OPHTHALMOSCOPIC EXAMINATION: No
HAEMATOLOGY: Yes
- Time schedule for examinations: at begin, middle after 2 weeks and the end of study (4 weeks)
- Animals fasted: No data
- Parameters: haemoglobin concentration / erythrocyte count / total leukocyte count / differential leukocyte count /
CLINICAL CHEMISTRY: No
- Animals fasted: No data
- Parameters: No data
URINALYSIS: Yes
- Time schedule for examinations: prior to, mid way and at the end of the study.
- Parameters: protein / sugar - Sacrifice and pathology:
- yes
- Other examinations:
- no data
- Statistics:
- no data
Results and discussion
Results of examinations
- Clinical signs:
- no effects observed
- Mortality:
- no mortality observed
- Details on results:
- Loss of some organ weights.
No mortality during the study.
WEIGHT: there were no changes in body weights during the study.
URINALYSIS: no significant values.
HEMATOLOGY: all the hematological findings were within normal limits.
PATHOLOGY: no toxic reaction, except some tendency to decrease in testes weights, was observed and the spleen weights showed a tendency to increase. A gross pitting of the kidney surface was observed in 2 of the 1% treated animals and 3 of the 10%.
A large spleen was observed in 2 animals treated at 1%.
Principal changes were seen in the examination of the skin: grossly in both control and experimental animals, dryness and crusting of the surface was observed. Microscopic changes ranging from atrophy of the epidermis to ulceration and inflammation were seen.
A number of observations were drawn during this study: marked irritation of the treated area in the first week of application. Control animals receiving the base alone exhibited similar changes although less marked.
The skin changes were of 2 sorts:
- an incrustration resembling an extremly heavy dandruff, perhaps made up of skin plus crystals of PDMB
- a sloughing of skin in large areas.
The skin appeared tanned but points of attachment to the lower dermis were raw and sensitive when the sloughs was disattached. At the end of the month, advanced healing was present in all the rabbits even though daily treatment was continued. Low on the ventral side of the shaved area were the more extensive sloughs. This effect could be attributed to the accumulation of excess material which ran down the depilated area and was held by the fur at the site of the severe damage. The ears of the rabbits on the dorsal aspect lost hair and were irritated. Since the ears were frequently laid back on the areas that were treated, the contact might account for this effect. In some rabbits, certain areas exhibited a rapid regrowth of hairs creating a "patchy" effect. In these patches of longer hair, tree new skin was invariably raw and sensitive to a greater degree than elsewhere. It was possible that larger quantities of the lotion were held in such patches for a longer time.
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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