Registration Dossier
Registration Dossier
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EC number: 205-771-9 | CAS number: 150-78-7
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: No enough details. Documentation is insufficient for assessment.
Data source
Reference
- Reference Type:
- publication
- Title:
- Short-term toxicity tests on the mono and di methyl ethers of hydroquinone
- Author:
- Hodge HC, Sterner JH, Maynard EA, Thomas J.
- Year:
- 1 949
- Bibliographic source:
- J. Ind. Hyg. Toxicol. 31, 79-92.
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- acute toxicity by i.p. route
- GLP compliance:
- no
Test material
- Reference substance name:
- 1,4-dimethoxybenzene
- EC Number:
- 205-771-9
- EC Name:
- 1,4-dimethoxybenzene
- Cas Number:
- 150-78-7
- Molecular formula:
- C8H10O2
- IUPAC Name:
- 1,4-dimethoxybenzene
- Details on test material:
- no data
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- no data
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- not specified
- Details on exposure:
- - Doses / concentrations:
Groups of 10 to 22 mice were given doses of paradimethoxybenzene ranging from 30 to 80 mg per animal, as follow:
- 10 animals in group treated with 30 mg (average body weight was 29 gm). Dose: 1034 mg/kg
- 10 animals in group treated with 35 mg (average body weight was 29 gm). Dose: 1207 mg/kg
- 22 animals in group treated with 40 mg (average body weight was 27 gm). Dose: 1481 mg/kg
- 20 animals in group treated with 50 mg (average body weight was 27 gm). Dose: 1852 mg/kg
- 10 animals in group treated with 60 mg (average body weight was 25 gm). Dose: 2400 mg/kg
- 10 animals in group treated with 70 mg (average body weight was 27 gm). Dose: 2592 mg/kg
- 12 animals in group treated with 80 mg (average body weight was 25 gm). Dose: 3200 mg/kg - Doses:
- 30; 35; 40; 50; 60; 70; 80 mg/animal corresponding to 1034; 1207; 1481; 1852; 2400; 2592; 3200 mg/kg bw.
- No. of animals per sex per dose:
- 10 to 22 animals per dose group, sex unspecified
- Control animals:
- not specified
- Details on study design:
- no data
- Statistics:
- no data
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 1 100 mg/kg bw
- Mortality:
- The 30 mg dose killed 30%,
the 35 mg dose killed 70%,
the 40 mg dose killed 73%,
the 50 and 60 mg dose killed 80%,
the 70 and 80 mg dose killed 100% of the treated animals. - Clinical signs:
- Mice given paradimethoxybenzene intraperitoneally developed a wobbly gait immediately following injection. This was followed in a few minutes by paralysis of the hind quarters, accompanied by spasms perhaps of anoxial origin. At the higher doses, mice appeared to be in a narcosis about 15 minutes after injection. Some mice still exhibited degrees of anesthesia as long as 18 hours after injection.
- Body weight:
- no data
- Gross pathology:
- no data
- Other findings:
- no data
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
