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Diss Factsheets
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EC number: 275-809-7 | CAS number: 71662-46-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 2 015
Materials and methods
Test material
- Reference substance name:
- Di-n-octyl phthalate
- IUPAC Name:
- Di-n-octyl phthalate
- Test material form:
- other: liquid
- Details on test material:
- - Name of test material (as cited in study report): Di-n-octyl phthalate
Constituent 1
Test animals
- Species:
- rat
Administration / exposure
- Route of administration:
- oral: gavage
- Duration and frequency of treatment / exposure:
- single
Doses / concentrations
- Remarks:
- Doses / Concentrations:
300 mg/kg
Results and discussion
Metabolite characterisation studies
- Metabolites identified:
- yes
- Details on metabolites:
- Phthalic acid (PA), mono-n-octyl phthalate (MnOP) and monocarboxy propyl phthalate (MCPP) being excreted in the urine
at least five other oxidative metabolites at concentrations much higher than MnOP were also detected: monocarboxy methyl phthalate
(MCMP), mono-(5-carboxy-n-pentyl) phthalate (MCPeP), mono-(7-carboxy-n-heptyl) phthalate (MCHpP), mono-hyrdoxy-n-octyl phthalate
(MHOP) and mono-(7-oxo-octyl) phthalate (MOOP).
MCPP was the major metabolite excreted (mean urinary level of 163.3 µg/mL) followed by MCHpP (mean urinary level of 71.6 µg/mL) after 24 hours.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results: low bioaccumulation potential based on study results
Overall, elimination of DnOP and their respective metabolites is rapid, as for other assessed phthalates. - Executive summary:
In the oral study conducted by Silva et al. (2005), the metabolism of Di-n-octyl phthalate (DnOP) in rats (administered one day at 300 mg/kg bw/day via gavage) resulted in Phtalic acid (PA), mono-n-octyl phthalate (MnOP) and monocarboxy propyl phthalate (MCPP) being excreted in the urine. At least five other oxidative metabolites at concentrations much higher than MnOP were also detected: monocarboxy methyl phthalate (MCMP), mono-(5-carboxy-n-pentyl) phthalate (MCPeP), mono-(7-carboxy-n-heptyl) phthalate (MCHpP), mono-hyrdoxy-n-octyl phthalate (MHOP) and mono-(7 -oxo-octyl) phthalate (MOOP). MCPP was the major metabolite excreted (mean urinary level of 163.3 µg/mL) followed by MCHpP (mean urinary level of 71.6 µg/mL) after 24 hours. Furthermore, the toxicokinetics of DnOP metabolites supports the postulated biphasic elimination pattern of DnOP with initial rapid clearance of all in vivo DnOP metabolites followed by a slow elimination phase. It was also suggested that, in rats, the major pathway for DnOP metabolism involves ω-oxidation followed by β oxidation in vivo. The metabolite levels decreased significantly over the following 24 hours, although MCPP, MCHpP, MHOP and MOOP were still detectable four days after dosing. The average levels of oxidative urine metabolites when collected 48-hours (day 2) after dosing were approximately 95% lower than in the first 24-hour urine collection.
Silva MJ, Kato K, Gray EL, Wolf C, Heedham LL & Calafat AM 2005. Urinary metabolites of di-n-octyl phthalate in rats. Toxicology, 210:123–133 cited in NICNAS, 2015
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