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EC number: 275-809-7 | CAS number: 71662-46-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1994-07-04 to 1994-07-08
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline study with acceptable restrictions
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.1 (Acute Toxicity for Fish)
- GLP compliance:
- yes
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): WITAMOL 118
- Substance type: product
- Physical state: liquid
- Stability under test conditions: no data
- Storage condition of test material: no data
- Other: none - Analytical monitoring:
- yes
- Details on sampling:
- - Concentrations: WAF
- Sampling method: For analytical determination a sample of each daily freshly prepared stock solution was directly taken. For stability measurement one sample without fish was maintained for 24 hours and then analyzed.
- Sample storage conditions before analysis: no data - Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Method: 1 g test substance was given into 1L drinking water, stirred for 18 hours, subsequently filtered. The test solutions were freshly prepared every day. - Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
- Details on test organisms:
- TEST ORGANISM
- Common name: zebrafish
- Strain: Brachydanio rerio
- Source: West Aquarium, Bad Lauterberg, Germany
- Age at study initiation (mean and range, SD): not mentioned
- Length at study initiation (length definition, mean, range and SD): 3 ± 0.5 cm, no further details mentioned
- Weight at study initiation (mean and range, SD): approx. 0.13 g mean weight
- Method of breeding: not mentioned
- Feeding during test: none
ACCLIMATION
- Acclimation period: 14 days
- Acclimation conditions (same as test or not): The fish were kept in 200 L earthenware basins, or in 300 L glass aquariums in flow rate.
- Type and amount of food: TetraMin, administration in an amount of approx. 1 % of body weight
- Feeding frequency: daily
- Health during acclimation (any mortality observed): The animals showed a normal behaviour pattern at the beginning of the test and were free from visible diseases. The mortality rate during the holding phase was <5% seven days before the beginning of the test. - Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 96 h
- Post exposure observation period:
- none
- Hardness:
- 12.3 °dH
- Test temperature:
- 20 - 22 °C
- pH:
- 7.8 - 8.5
- Dissolved oxygen:
- 92 - 105 % O2 saturation
- Salinity:
- not mentioned
- Nominal and measured concentrations:
- Nominal: WAF
Measured: 0.32 mg/L (mean of freshly prepared test solutions) - Details on test conditions:
- TEST SYSTEM
- Test vessel:
- Type (delete if not applicable): not mentioned
- Material, size, headspace, fill volume: approx. 30 L, 10 L fill volume, no further details mentioned
- Aeration: continously, no further details mentioned
- Renewal rate of test solution (frequency/flow rate): daily renewal
- No. of organisms per vessel: 10
- No. of vessels per concentration (replicates): 1
- No. of vessels per control (replicates): 1
- Biomass loading rate: 0.13 g fish/L
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: drinking water, Gelsenwasser AG, Germany
no further details mentioned
- Intervals of water quality measurement: not mentioned
OTHER TEST CONDITIONS
- Adjustment of pH: no
- Photoperiod: 16 hours light, 8 hours darkness
- Light intensity: not mentioned
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) : mortality after 24, 48, 72 and 96 hours; pH, temperature, O2 saturation at the end of the test
TEST CONCENTRATIONS
- Spacing factor for test concentrations: not mentioned
- Range finding study: not performed - Reference substance (positive control):
- no
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 0.32 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Details on results:
- - Behavioural abnormalities: not determined
- Observations on body length and weight: not performed
- Other biological observations: none
- Mortality of control: 0/10
- Other adverse effects control: none
- Abnormal responses: none
- Any observations (e.g. precipitation) that might cause a difference between measured and nominal values: not mentioned
- Effect concentrations exceeding solubility of substance in test medium: not applicable - Results with reference substance (positive control):
- no reference substance tested
- Reported statistics and error estimates:
- no statisitcs performed
- Sublethal observations / clinical signs:
concentration[mg/L] No. of fish at start of study observation period 24 h 48 h 72 h 96 h No. dead mortality [%] No. dead mortality[%] No. dead mortality[%] No. dead mortality[%] control 10 0 0 0 0 0 0 0 0 0.32 10 0 0 0 0 0 0 0 0 - Validity criteria fulfilled:
- yes
- Conclusions:
- In the range of water solubility not toxic under test conditions.
- Executive summary:
In the range of water solubility 1,2-Benzenedicarboxylic acid, di-C8-10-alkyl esters were not toxic under test conditions.
The 96 hour LC50 was in excess of 0.32 mg/L, the highest concentration investigated which was at or in excess of the water solubility of the substance.
Reference
Description of key information
In the range of water solubility 1,2-Benzenedicarboxylic acid, di-C8-10-alkyl esters were not toxic under test conditions. The 96 hour LC50 was in excess of 0.32 mg/L, the highest concentration investigated which was at or in excess of the water solubility of the substance.
Key value for chemical safety assessment
Additional information
The acute toxicity of various phthalate esters was assessed in a number of freshwater fish species over a 96 hour period. No toxicity was observed up to the highest concentration tested. The 96 hour LC50 of 1,2-Benzenedicarboxylic acid, di-C8-10-alkyl esters was in excess of 0.32 mg/L, the highest concentration investigated which was at or in excess of the water solubility of the substance.
For the structurally related substances 1,2-Benzenedicarboxylic acid, diundecyl esters the LC50 in rainbow trout was in excess of 1.4 mg/L, in fathead minnow was in excess of 1.3 mg/L and in bluegill was in excess of 0.73 mg/L. These values represent the highest concentrations examined which were at or in excess of the water solubility of the phthalates.
Adams et al. (1995) concluded in general that phthalate esters with alkyl chain lengths of six carbon atoms or more were not acutely toxic at concentrations up to their respective limits of water solubility. In addition, DeFoe et al. (1990) reported for di-n-octyl-ortho-phthalate, di-n-octyl-iso-phthalate and di-n-octyl-tere-phthalate that they were not acutely toxic to fathead minnow at concentrations that exceeded the water solubility estimates for each of the phthalates.
Acute toxicity to a marine species, sheepshead minnow, has also been determined with the structurally related substance Diundecyl phthalate. The 96 hour LC50 was in excess of 0.22 mg/L, the highest concentration investigated which was at or in excess of the water solubility of the substance.
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