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EC number: 201-134-4 | CAS number: 78-70-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- No data
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Remarks:
- Although an old study (1970) and not fully compliant with OECD 402, and non GLP, the report is well documented, and the design is considered scientifically accepted.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 970
- Report date:
- 1970
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- yes
- Remarks:
- 3 animals per dose group of unspecified sex, post exposure (observation) only 7 days, area exposed not specified, animal weight slightly too low, no information on housing conditions.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Linalool
- EC Number:
- 201-134-4
- EC Name:
- Linalool
- Cas Number:
- 78-70-6
- Molecular formula:
- C10H18O
- IUPAC Name:
- 3,7-dimethylocta-1,6-dien-3-ol
- Details on test material:
- - Name of test material (as cited in study report): Linalool
- Physical state: clear liquid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: albino
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: approx. 1500 to 2300 g.
ENVIRONMENTAL CONDITIONS: No data
IN-LIFE DATES: No data
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Type of wrap if used: Saran Wrap
REMOVAL OF TEST SUBSTANCE
- Washing: Gently removed
- Time after start of exposure: 24 hours
TEST MATERIAL
- Amounts applied: 2500, 5000 and 10000 mg/kg/bw
- Concentration: Undiluted - Duration of exposure:
- 24 hours
- Doses:
- 2500, 5000 and 10000 mg/kg/bw
- No. of animals per sex per dose:
- 3
- Control animals:
- yes, concurrent no treatment
- Details on study design:
- - Duration of observation period following administration: 7 days
- Frequency of observations and weighing: observation: daily; weighing: at start and termination (at 7 days) of the study
- Necropsy of survivors performed: Yes
- Other examinations performed: clinical signs, hematology and clinical chemistry were conducted on survivors at five days of the studies.
Hematology: Erythrocyte, leucocyte and differential leucocyte counts; hematocrit; hemoglobin.
Clinical chemistry: Serum glutamic oxaloacetic transaminase (SCOT): glucose; blood urea nitrogen (BUN); serum alkaline phosphatase (SAP); total serum protein; serum albumin; bilirubin; lactic acid dehydrogenase (LDH); cholesterol; serum calcium; serum phosphate; and uric acid, using the SMA-12 methods. - Statistics:
- The acute dermal LD50 was calculated by the method of Weil (Biometrics 8, 3, p.249, Sept., 1952).
Results and discussion
- Preliminary study:
- Not applicable
Effect levels
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 5 610 mg/kg bw
- 95% CL:
- >= 3 578 - <= 8 374
- Mortality:
- At 5000 mg/kg bw one out of three animals died at day 5.
At 10000 mg/kg bw all three rabbits were dead within the first 24 hours of the study. - Clinical signs:
- other: - Other observations: Signs of intoxication were depression, coma and death. Signs developed within 24 hours following application of the test material, and survivors were normal after 5 days. On removal of the bandages, the skins of the rabbits at all tr
- Gross pathology:
- At autopsy no significant gross pathology was noted which could be attributed to the dermal application of the test substance.
- Other findings:
- - Other observations: All hematology and clinical chemistry values, conducted on survivors at five days of the studies, appeared to be within normal limits and are comparable to control values generated in this laboratory.
Any other information on results incl. tables
Not relevant
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The dermal LD50 of linalool in rabbits is calculated to be 5610 mg/kg, with confidence limits of 8374 - 3578 mg/kg, under the conditions of this study. The substance does not need to be classified for acute dermal toxicity according to the criteria outlined in Regulation (EC) 1272/2008 (CLP/EU-GHS).
- Executive summary:
The substance has been tested in an acute dermal toxicity test (similar to OECD 402, test system: Rabbit). Three dose levels, 2500, 5000 and 10000 mg/kg/bw, were applied undiluted for 24 hours. Untreated animals served as control.
On removal of the bandages, the skins of the rabbits at all treatment levels appeared blanched, with moderate erythema and slight edema of the skin surrounding the blanched areas. At 24 hours after removal, the skin of surviving rabbits appeared normal.
At 5000 mg/kg bw one out of three animals died at day 5. At 10000 mg/kg bw all three rabbits were dead within the first 24 hours of the study.
All hematology and clinical chemistry values, conducted on survivors at five days of the studies, appeared to be within normal limits and are comparable to control values generated in this laboratory. At seven days the surviving rabbits showed a normal weight gain for the period (at 2500 and 5000 mg/kg).
At autopsy no significant gross pathology was noted which could be attributed to the dermal application of the test substance.
Signs of intoxication were depression, coma and death. Signs developed within 24 hours following application of the test material, and survivors were normal after 5 days.
The substance does not need to be classified for acute dermal toxicity according to criteria Regulation (EC) 1272/2008/EC), as the LD50 is calculated to be 5610 mg/kg bw, with confidence limits of 8374 - 3578 mg/kg bw, under the conditions of this study.
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