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Diss Factsheets
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EC number: 201-134-4 | CAS number: 78-70-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
Summary of the results of the toxicity tests presented in this dossier:
Guideline |
Test species |
Endpoint |
Result, mg/l |
Remarks |
OECD 203 |
Salmo gairdneri (new name Oncorhynchus mykiss) |
96h-LC50 |
27.8 |
Key study, Rel. 1, GLP Incipient LC50 reached after 24h |
OECD 202 |
Daphnia magna |
48h-EC50 Immobility |
59 |
Key study, Rel. 1, GLP |
DIN 38412 L9 |
Scenedesmus subspicatus (new name Desdodesmus subspicatus) |
96h-EC50 96h-EC10 Growth rate |
156.7 54.3 |
Key study, Rel. 2 |
OECD 209 |
Activated sludge |
3h-EC50 and EC10 Respiration |
> 100 |
Key study, Rel. 1, GLP |
An OECD SIDS document was produced for linalool in 2002. The SIDS document contains the results of more studies on the aquatic toxicity, which are summarised in the table below:
Test species |
Endpoint |
Result, mg/l |
Remarks |
Fish |
|
|
|
Leuciscus idus |
96h-LC50 |
32 |
Rel. 2, SIDS/IUCLID file (ref. 9) (Derived from geometric mean: LC0 = 22 and LC100<46) |
Oncorhynchus mykiss |
LC50 |
28.8 |
Rel. 4, SIDS/IUCLID file (ref. 40, EPA fact sheet) |
Lepomis macrochirus |
LC50 |
36.8 |
Rel. 4, SIDS/IUCLID file (ref. 40, EPA fact sheet) |
Invertebrates |
|
|
|
Daphnia magna |
48h-EC50 |
20 |
Rel. 2, Guideline 84/449/EEC SIDS/IUCLID file (ref. 11) |
Aquatic invertebrates |
EC50 |
36.7 |
Rel. 4, EPA fact sheet SIDS/IUCLID file (ref. 40) |
Algae |
|
|
|
Chlorella pyrenoidosa |
Algae grown on agar; no effect from paper disk dipped in 1 g linalool/l and placed on colony, but platewide lightening at 10 g/l |
Rel. 4, SIDS/IUCLID file (ref. 71) |
In the SIDS document, linalool is described as a substance of moderate toxicity in standard acute tests with fish, daphnia and algae with all LC50/EC50 values ranging between 20 and 90 mg/l. (Remark: the value 90 is based on the algae test (key study) with biomass as the endpoint). All four fish LC50s are very close, ranging from 27.8 -36.8 mg/l. The results in the studies on invertebrates range from 20 to 59 mg/l. The tests with algae show effect only above the levels of the other two groups.
The SIDS document concludes that based on the acute toxicity data there is no indication for a specific, high toxicity to any of the systematic groups tested. Thus an assessment factor of 100 was chosen for the derivation of the PNEC.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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