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EC number: 201-964-7 | CAS number: 90-05-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: No information was available about the test substance. No information was available about the control group and the test concentrations.
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: screening test
- Deviations:
- not specified
- GLP compliance:
- not specified
- Analytical monitoring:
- not specified
- Vehicle:
- not specified
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: Daphnia magna
- Source: no data
- Age at study initiation: 12 +/- 12 hours old.
- Method of breeding: no data
- Feeding during test:
- Food type: the food suspension was prepared by weighing 0.25 g of powdered grass and 5 g of enriched trout fry granules. This mixture was added to 125 ml of Lake Superior water and mixed vigorously in a blender for 5 min. An additional 25 ml of lake water was used to rinse out the blender. The suspension was then filtered through N° 20 bolting cloth.
- Amount: 0.2 ml/ 200 ml of suspension
- Frequency: at the beginning of each test
ACCLIMATION: no data - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 4 d
- Test temperature:
- 18 +/- 1°C
- Details on test conditions:
- TEST SYSTEM
- Test vessel:
- Type: closed
- Material, size, headspace, fill volume: 4 beakers filled with 200 ml of solution each
- Aeration: no data
- No. of organisms per vessel: 5
- No. of vessels per concentration: 3 or more
- No. of vessels per control: no data
- No. of vessels per vehicle control: no data
WATER PARAMETERS
- Source/preparation of dilution water: Non-filtered and non-chlorinated Lake Superior water from the Duluth National Water Quality Laboratory (NWQL).
TEST MEDIUM PARAMETERS: no data
OTHER TEST CONDITIONS
- Adjustment of pH: no
- Photoperiod: 16 hours photoperiod
- Light intensity: fluorescent bulbs, a combination of Durotest (Optima FS) and wide spectrum Grow-lux bulbs, provided an intensity of 475 foot-candles at the air-water interface.
- Test temperature: 18 +/- 1°C
- pH: no observed pH change
- dissolved oxygen: no data
EFFECT PARAMETERS MEASURED: mortality; the daphnia were counted each day for 4 days and the number of survivors recorded.
TEST CONCENTRATIONS: four dose levels, without any details
Reference substance (Positive control): no data - Duration:
- 4 d
- Dose descriptor:
- EC50
- Effect conc.:
- 25.9 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Details on results:
- LC50 were calculated on 48 hours but exposure/ observation period was continued on 4 days.
- Reported statistics and error estimates:
- For each compound a graph was prepared plotting log percent survivors vs. time in hours. From this plot it was possible to determined the percent survivors, for each dose level at 48 h. The 48-h percent survival figures were converted to probit transformation tables. These values were plotted vs. log molar concentration. The log LC50 molar concentration can then be found by observing the log molar concentration value which corresponds to a probit value of 5. The probit values and log molar concentration values were introduced into a least squares computer program which calculated the LC50 and also gave the correlation of the line to the data points.
This method for determining the 48-h LC50 value, has the advantage of a 4-day observation period. The inconsistencies which arise when animals are counted only once (at 48h) are thereforeaveraged out, resulting in greater reproductibility. - Validity criteria fulfilled:
- not specified
- Conclusions:
- Harmful for aquatic organisms.
- Executive summary:
The 48-hr acute toxicity of guaiacol to Daphnia magna was studied under static conditions. Daphnids were exposed to test chemical (concentrations not specified) for 96 hr. Mortality was observed daily. The 48-hour LC50 was determined graphically by the method of log probit and was found to be 25.9 mg/L.
Based on the results of this study, guaiacol would be classified as harmful to Daphnia magna in accordance with the classification system of the EU.
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- no data
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: This study was conducted following a standardised method.
- Qualifier:
- according to guideline
- Guideline:
- other: AFNOR T90301 of april 1974, modified according to AFNOR T95B DOC 19
- Deviations:
- not specified
- GLP compliance:
- no
- Analytical monitoring:
- not specified
- Vehicle:
- not specified
- Details on test solutions:
- - Method: The test substance was diluted in bidistilled water at the concentration slightly higher than the expected toxicity threshold.
- Controls: no data - Test organisms (species):
- Daphnia magna
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 24 h
- Details on test conditions:
- TEST SYSTEM: no data
WATER PARAMETERS
- Source/preparation of dilution water: Reconstituted River water
TEST MEDIUM PARAMETERS: no data
OTHER TEST CONDITIONS: no data
EFFECT PARAMETERS MEASURED: immobility
TEST CONCENTRATIONS: no data - Duration:
- 24 h
- Dose descriptor:
- IC50
- Effect conc.:
- 63 mg/L
- Nominal / measured:
- not specified
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: 45-87
- Reported statistics and error estimates:
- no
- Validity criteria fulfilled:
- not specified
- Executive summary:
The 24-hr-acute toxicity of guaiacol to Daphnia magna was studied under static conditions following the AFNOR T90301 of april 1974, modified according to AFNOR T95B DOC 19 . Daphnids were exposed to test chemical (concentrations not detailed), and Mortality/immobilization were observed. The 24- hour IC50 was 63 mg/L.
Based on the results of this study, gaiacol would be classified as harmful to Daphnia magna in accordance with the classification system of the EU.
Referenceopen allclose all
Description of key information
Two studies performed with methods equivalent to EC standards reported EC50 24H on Daphnia magna = 63 mg/L (Palla & Dion, 1983) and EC50 48H = 25.9 mg/l on the same species (Kopperman et al., 1974).
Key value for chemical safety assessment
Additional information
Regarding these 2 studies, guaiacol is considered as harmful for Daphnia.
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