Registration Dossier
Registration Dossier
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EC number: 430-110-8 | CAS number: 183476-82-6
Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- January 13 - February 05, 1997
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study has been performed according to OECD and EC guidelines and according to GLP principles.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 997
- Report date:
- 1997
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Qualifier:
- according to guideline
- Guideline:
- other: Directive 92/69/EEC, A.8, HPLC-method
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
Test material
- Details on test material:
- - Name of test material (as cited in study report): Nikkol VC-IP
- Substance type: Colourless to light yellow transparent liquid
- Physical state: Liquid
- Stability under test conditions: stable
- Storage condition of test material: In refrigerator in the dark
Constituent 1
Study design
- Analytical method:
- high-performance liquid chromatography
Results and discussion
Partition coefficient
- Type:
- log Pow
- Partition coefficient:
- > 6.2
- Temp.:
- 24 °C
- Remarks on result:
- other: pH unknown
- Details on results:
- In the HPLC chromatograms of NIKKOL VC-IP, detected at 236 nm and recorded for 11 minutes, no test substance peak was observed. Because
during NOTOX Project 186222 ('Development and validation of an analytical method for NIKKOL VC-IP'), test substance was detected at 236 nm at a comparable concentration level but with a different mobile phase, it was concluded that if test substance had eluted from the column, it had been detected. From the four HPLC chromatograms of 2,4-DDT (i.e. a reference substance with known log Pow of 6.2), the retention time of 2,4-DDT wasdetermined to be 9.4 minutes (mean value). The temperature of the mobile phase was 24°C during the measurements. Comparing the results for
the test substance with the results for 2,4-DDT, it was concluded that the partition coefficient (n-octanol/water) of NIKKOL VC-IP is > 1.6 x 10^6
(log Pow > 6.2).
Applicant's summary and conclusion
- Conclusions:
- The partition coefficient (n-octanol/water) of NIKKOL VC-IP is > 1.6x10^6 (log Pow > 6.2).
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