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Diss Factsheets
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EC number: 480-290-7 | CAS number: 120100-77-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- repeated dose toxicity: oral
- Adequacy of study:
- other information
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: 96/54/EWG, B.26; OECD 408 (1998)
- GLP compliance:
- yes
- Limit test:
- no
Test animals
- Species:
- other: rat, Wistar Hsd Cpb:WU
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- other: diet
- Details on oral exposure:
- Method of administration:
oral - Duration of treatment / exposure:
- Test duration: 90 days
- Frequency of treatment:
- Dosing regime: 7 days/week
- No. of animals per sex per dose:
- Male: 10 animals at 0 mg/kg bw/day
Male: 10 animals at 1.19 mg/kg bw/day
Male: 10 animals at 12.34 mg/kg bw/day
Male: 10 animals at 120.19 mg/kg bw/day
Male: 10 animals at 1203.8 mg/kg bw/day
Female: 10 animals at 0 mg/kg bw/day
Female: 10 animals at 1.63 mg/kg bw/day
Female: 10 animals at 16.08 mg/kg bw/day
Female: 10 animals at 162.49 mg/kg bw/day
Female: 10 animals at 1436.3 mg/kg bw/day
Results and discussion
Results of examinations
- Details on results:
- Clinical observations:
No animal died prescheduled.
No clinical signs attributable to the test substance were
noted up to 15000 ppm. The reduced food consumption (- 13 %)
in females ingesting 15000 ppm corresponded to a slight
but statistically significant depression in body weights
(- 10 %) and body weight gain at termination. There was no
effect on food consumption and body weight gain in males up
to 15000 ppm.
No test substance-related effects were detected during
functional observational battery including functional
observations, behavioural assessments, reflex testing; and
motor activity measurements.
Laboratory findings:
Haematological investigations revealed no toxic effect on
red and white blood cells or coagulation parameters.
Isolated means marked as statistically significant are of no
toxicological relevance, because the deviations to control
means were too small and not dose-related distributed.
Clinical biochemistry tests revealed no indications of toxic
effects on enzyme activities as well as substrate and
electrolyte concentrations in plasma.
No test substance-related differences in urinalysis
parameters were noted when compared with the control values.
Effects in organs:
There was statistically significant increase in relative
brain and pituitary weight in females at 15000 ppm, which
considered being due to the reduced body weight and,
therefore secondary.
At necropsy pale discoloration of the liver (incidence:
0/3/4/3/4) and distinct lobulation of the liver (2/4/7/5/4)
were reported in several animals of all dose groups. No
histopathological correlate could be found to the
macroscopic findings noted in the liver.
Histopathology revealed an increase in number (incidence:
0/0/1/2/4) and severity score of splenic haematopoietic
activity in 15000 ppm females. The hemosiderin content of
the spleen was similar in untreated and treated animals of
both sexes.
Gross and histopathological investigations on other organs
and tissues as well as organ weight measurements gave no
indication of test substance-related functional or
morphological changes in both sexes.
Effect levels
- Dose descriptor:
- NOAEL
- Effect level:
- 1 203.8 mg/kg bw/day (nominal)
- Basis for effect level:
- other: original NCD unit is mg/kg/day.
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- Classified as: Not classified
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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