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EC number: 696-441-7 | CAS number: 256473-05-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Dose descriptor:
- LC50
- Value:
- 5.192 mg/m³
Acute toxicity: via dermal route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Additional information
In total three studies are available for the acute oral, dermal and inhalation toxicity.
The acute oral toxicity of ITTFEP (purity 82.3%) to rat was determined in a GLP compliant test according to OECD 423 (Sommer 2000). Since the study was performed under GLP and according the guideline and based on the good documentation the study was awarded with Klimisch 1. The acute toxicity testing in 3 male and 3 female rats showed that the LD50 of the test item was > 2000mg/kg body weight. No mortalities were observed. The body weight evolution was not influenced during the 14-day observation period. There were no in-life observations indicating treatment-related systemic effects on any males. Slight reduced activity was observed in all females on the treatment day which lasted in once female (no. 101) through day 1, and in one female (no. 102) through day 2, slightly hunched posture in two females (no 101 and 103) on the treatment day through day 1, and in one female (no. 102) on the treatment day through day 4, slight piloerection in all females on the treatment day, which lasted in one female (no. 102) through day 2. In addition, skin cold to touch, recumbency, and slight dyspnea were seen in one female (no. 102) on days 1 and 2. All females appeared normal on day 5 after treatment. The obtained results are considered as relevant for the risk assessment.
The acute dermal toxicity of ITTFEP (purity 82.3%) to rat was determined in a GLP compliant test according to OECD 402 (Sommer 2000). Since the study was performed under GLP and according the guideline and based on the good documentation the study was awarded with Klimisch 1. The acute dermal toxicity testing in 5 male and 5 female rats showed that the LD50 of the test item was > 2000mg/kg body weight. No mortality was observed. There were no remarkable clinical observations for any animal. There were only slight effects on body weight development in males. A slight loss of body weight was recorded in one female during the first week after treatment. Necropsy examinations revealed no observable abnormalities. There were no remarkable findings for local tolerance for any animal. The obtained results are considered as relevant for the risk assessment.
The acute 4 -h nose-only inhalation toxicity of ITTFEP (purity 82.3%) to rat was determined in a GLP compliant test according to OECD 403, EU method B.2 and EPA OPPTS870.1300 (Decker et al. 2001). Since the study was performed under GLP and according the guideline and based on the good documentation the study was awarded with Klimisch 1.
The acute inhalation toxicity testing in 5 male and 5 female rats showed that the LD50 of the test item was > 5.192 mg/L (limit test, analytically measured). Several slight to moderate clinical signs were observed. The body weight evolution was influenced during the first three days but recovered until day 14. All treated animals were free from poisoning symptoms after 5 days at the latest. The obtained results are considered as relevant for the risk assessment.
In summary, oral, dermal and inhalation acute toxicity were tested in various studies with ITTFEP and its technical product, demonstrating that LD50 values were close to (due to the lower content of active ingredient) or above the limit dose of 2000 mg/kg bw or 5 mg/L. Therefore, there is no need for classification and labelling.
Justification for classification or non-classification
Oral, dermal and inhalation acute toxicity were tested in various studies with ITTFEP and its technical product, demonstrating that LD50 values were close to (due to the lower content of active ingredient) or above the limit dose of 2000 mg test item /kg bw or 5 mg/L. Therefore, there is no need for classification and labelling.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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