Registration Dossier
Registration Dossier
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EC number: 233-046-7 | CAS number: 10025-87-3
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 4 (not assignable)
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- No information
- Author:
- Molodkina, N.N
- Year:
- 1 984
- Bibliographic source:
- Gig. Truda Prof. Zabol. 10, 30 (1971);|cited in: MAK-Begruendung "Phosphoroxidchlorid" (1984)
- Reference Type:
- secondary source
- Title:
- No information
- Author:
- Molodkina, N.N.
- Year:
- 1 984
- Bibliographic source:
- Toksikol. Nov. Prom. Khim. Veshch. 13, 107|(1973);|cited in: MAK-Begruendung "Phosphoroxidchlorid" (1984)
Materials and methods
- Principles of method if other than guideline:
- Method: other: no data
- GLP compliance:
- no
Test material
- Reference substance name:
- phosphorus oxychloride
- IUPAC Name:
- phosphorus oxychloride
- Details on test material:
- no data on purity of the compound
Constituent 1
Test animals
- Species:
- rabbit
Test system
- Type of coverage:
- open
- Preparation of test site:
- shaved
- Amount / concentration applied:
- undiluted
- Details on study design:
- Four drops (ca. 0.5 ml) of the undiluted test substance were applied to the shaved skin (area of ca. 4 x 5 cm2).
Results and discussion
In vivo
Results
- Irritation parameter:
- other: Description
- Remarks on result:
- other: Corrosive: Dermal edema, marked hemorrhagic cracks and poorly healing ulcera
- Irritant / corrosive response data:
- corrosive
- Other effects:
- Dermal edema, marked hemorrhagic cracks and poorly healing ulcera were observed.
Applicant's summary and conclusion
- Interpretation of results:
- corrosive
- Remarks:
- Migrated information
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