Registration Dossier
Registration Dossier
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EC number: 701-085-3 | CAS number: -
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1978
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1978
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- no
- Test type:
- standard acute method
Test material
- Reference substance name:
- Silicon dioxide
- EC Number:
- 231-545-4
- EC Name:
- Silicon dioxide
- Cas Number:
- 7631-86-9
- Molecular formula:
- O2Si
- IUPAC Name:
- dioxosilane
Constituent 1
- Specific details on test material used for the study:
- ZEO 49, ZEOSYL 113, ZEOSYL 200, and ZEOFREE 153 (not further specified)
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- water
- Details on dermal exposure:
- Four animals per group used, two each treated on the intact and abraded skin: The substance was mixed with distilled water to form an aqueous paste
- Duration of exposure:
- 24 h
- Doses:
- 2000, 3000, 4000, and 5000 mg/kg
- No. of animals per sex per dose:
- 4 per dose group
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing:
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, organ weights
Results and discussion
Effect levels
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality was observed.
- Clinical signs:
- other: No systemic signs of toxicity were observed.
- Gross pathology:
- Organ toxicity was not observed.
- Other findings:
- Local effect: very slight erythema (score 1 of 4), reversible after 2 days (ZEO 49), after 4 d (ZEOSYL) or 5 d (ZEOFREE) in one or a few animals.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
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