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Diss Factsheets
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EC number: 914-920-3 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- 1976
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Guideline study with acceptable restrictions (only raw data were reported, information on substance identity and composition is lacking and no batch no. is given. Guideline 402 is followed with deviations. Substance identity and composition is reliability with restrictions. No Statement from company owner is received on substance identity and composition mentioned in study report)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 976
- Report date:
- 1976
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- yes
- Remarks:
- only raw data were reported; very limited reported study; only 2 males and 2 females tested.
- GLP compliance:
- no
- Remarks:
- pre-GLP
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Aluminium sulphate
- EC Number:
- 233-135-0
- EC Name:
- Aluminium sulphate
- Cas Number:
- 10043-01-3
- Molecular formula:
- Al.3/2H2O4S
- IUPAC Name:
- Aluminium sulphate
- Reference substance name:
- aluminum sulphate, hydrate
- IUPAC Name:
- aluminum sulphate, hydrate
- Details on test material:
- - Name of test material (as cited in study report): aluminum sulfate, hydrate
- Physical state: granular, no further info
- Analytical purity: not reported
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Duration of exposure:
- 24 h
- Doses:
- 5000 mg/kg bw
- No. of animals per sex per dose:
- 2 males and 2 females
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: observations: daily; weighing: at start and end of the test
- Necropsy of survivors performed: yes
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality occurred following treatment and during the observation period at the 5000 mg/kgbw dose level.
- Clinical signs:
- other: Clinical observation data at the 5000 mg/kg bw dose: - Males: mild/moderate erythema. Both appear normal 2 days after treatment. - Females: moderate and severe erythema, small areas of haemorrhaging in places where large chunks of compound were pressed in
- Gross pathology:
- Animals autopsied in the 5000 mg/kg group showed no gross abnormalities, with the exception of 1 male animal which had pale lungs.
- Other findings:
- No further data
Any other information on results incl. tables
Date |
Sex |
Dose (mg/kg) |
# deaths |
Total # animals |
Clinical observations |
Necropsy observations |
15July1976 |
M |
5000 |
0 |
2 |
After unwrapping: - Mild/moderate erythema Day 2: - Appear normal |
One animal with pale lungs, other animal showed no gross abnormalities |
|
|
|
|
|
|
|
15July1976 |
F |
5000 |
0 |
2 |
Day 1: - Moderate and severe erythema - Small areas of haemorrhaging in places where large chunks of compound were pressed into the skin Day 2: - Appear normal |
No gross abnormalities |
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- CLP: not classified
DSD: not classified - Executive summary:
Aluminum Sulfate, Hydrate was evaluated for its acute dermal toxicity potential in New Zealand White rabbits. The study is equivalent to the OECD Guideline 402 (Acute Dermal Toxicity) with deviations. The study wasn’t designed and performed according to Good Laboratory Practice Standards.
For 24 hours 5000 mg/kg bw test substance is applied to the skin of 2 male and 2 female rabbits. This application produced some skin irritation such as erythema and haemorrhaging after treatment. No mortality occurred. All rabbits exhibited normal appearance and behaviour on day 2. The gross necropsy showed no significant gross changes, with the exception of 1 male animal which had pale lungs..
The Single Dose Acute Dermal LD50of Aluminum Sulfate, Hydrate applied to the skin for 24 hours, is greater than 5000 mg/kg bw. Therfore the test material was not classified according to OECD-GHS.
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