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EC number: 700-155-0 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- from 04 February 2011 to 01 April 2011
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The study was performed in accordance with OECD guideline and GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 011
- Report date:
- 2011
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- corn oil, peroxidised
- IUPAC Name:
- corn oil, peroxidised
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Deutschland GmbH, D-97633 Sulzfeld
- Age at study initiation: no data
- Weight at study initiation: between 150 and 174 g
- Fasting period before study: fasted overnight prior to dosing
- Housing: transparent macrolone cages (floor area 810 cm²), three animals per cage
- Diet: free access to a pelleted diet "Altromin 1324"
- Water (e.g. ad libitum): free access to bottles with domestic quality drinking water , which was acidified with hydrochloric acid to pH 2.5 in order to prevent microbial growth
- Acclimation period:at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature: ± 3°C
- Humidity (%): at least 30% and preferably not exceeding 70%
- Air changes: 10 times/hour
- Photoperiod: 12hrs dark / 12hrs light
IN-LIFE DATES: from 18 January 2011 to 8 March 2011
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- olive oil
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: no data
- Amount of vehicle (if gavage): 10 mL/kg
- Justification for choice of vehicle: lipophilic substance
MAXIMUM DOSE VOLUME APPLIED: 10 mL/kg
CLASS METHOD (if applicable)
- Rationale for the selection of the starting dose: 300 mg/kg was choosen as no data on the toxicity of the compound was known. - Doses:
- 300 and 2000 mg/kg bw
- No. of animals per sex per dose:
- 6 females per dose level
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing:
> clinical observations and mortality: 30 minutes, 2 hrs, 4 hrs and 6 hrs after the administration and thereafter daily
> body weight: on day 0, 7 and 14
- Necropsy of survivors performed: yes - Statistics:
- not applicable
Results and discussion
Effect levelsopen allclose all
- Sex:
- female
- Dose descriptor:
- LD0
- Effect level:
- 2 000 mg/kg bw
- Based on:
- test mat.
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality observed during te observation period.
- Clinical signs:
- Slight signs of toxicity were observed.
On the day of application after 30 minutes 2 hrs and 4 hrs, a hunched posture and/or piloerection were observed in 6 animals (3 in group 1 and 3 in group 2) receiving a dose of 300 mg/kg bw. After 4 hrs and 6 hrs the rats showed normal behaviour. From day 1 to the end of the observation period on day 14 all animals were free of any abnormalities.
On the day of application after 30 minutes piloerection was observed in 3 animals of group 3 receiving a dose of 2000 mg/kg bw. After 2 hrs and 4 hrs the rats showed a hunched posture and piloerection, whereas only piloerection was observed fter 6 hrs. From day 1 to the end of the observation period on day 14 all animals were free of any abnormalities.
In group 4 receiving a dose of 2000 mg/kg bw, piloerection was observed in all animals (3) on the day of application after 30 minutes, 2 hrs, 4 hrs and 6 hrs. From day 1 to the end of the observation period on day 14 all animals were free of any abnormalities. - Body weight:
- The development of the body weight was normal in all animals.
- Gross pathology:
- There were no pathological signs detected in the necropsy.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- oral LD50 > 2000 mg/kg bw in rat (no mortality)
- Executive summary:
In an acute oral toxicity study according to OECD TG 423 and GLP (Vaeth A., 2011), scored as validity 1 according to Klimisch criteria, groups of fasted Wistar rats (6 females/dose level) were given a single oral dose of « Corn oil, peroxidised » in olive oil at the doses of 300 and 2000 mg/kg bw and observed for 14 days. Clinical signs and mortality were checked frequently during the hours following administration of the test substance, and at least once a day thereafter. Body weight was measured just before administration of the test substance on day 0 and then on days 7 and 17.
Under the experimental conditions, the oral LD50 of the test substance « Corn oil, peroxidised » is higher than 2000 mg/kg in rats.
No mortality was observed during the observation period. On the day of application after 30 minutes to 6 hrs, a hunched posture and/or piloerection were observed in animals receiving the doses of 300 and 2000 mg/kg bw. After 4 hrs or 6 hrs the rats showed normal behaviour. From day 1 to the
end of the observation period on day 14 all animals were free of any abnormalities.
The development of the body weight was normal in all animals.
There were no pathological signs detected in the necropsy.
No classification for acute oral toxicity is warranted based on the absence of mortality up to a limit dose level, according to the criteria of EU GHS.
This study is classified as acceptable, as it is performed according to OECD guideline and GLP.
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