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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 202-879-8 | CAS number: 100-69-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 2000 - 2002.
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: A standard NTP (National Toxicology Program) protocol. Equivalent to OECD 471.
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 2 002
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- other: Standard NTP Protocol.
- Deviations:
- no
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 471 (Bacterial Reverse Mutation Assay)
- Deviations:
- yes
- Remarks:
- (only three Salmonella strains were tested)
- GLP compliance:
- not specified
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- 2-vinylpyridine
- EC Number:
- 202-879-8
- EC Name:
- 2-vinylpyridine
- Cas Number:
- 100-69-6
- Molecular formula:
- C7H7N
- IUPAC Name:
- 2-ethenylpyridine
- Details on test material:
- - Name of test material (as cited in study report): 2-vinylpyridine
Constituent 1
Method
Species / strain
- Species / strain / cell type:
- S. typhimurium, other: S. typhimurium TA 100, TA 1535 and TA 98.
- Metabolic activation:
- with and without
- Metabolic activation system:
- Induced male Sprague Dawley rat liver S9 mix and induced male Syrian hamster liver S9 mix.
- Test concentrations with justification for top dose:
- TA 1535: 0, 100, 333, 1000, 2000, 3333, 4000 μg/plate.
TA 98 and TA 100: 0, 100, 333, 1000, 2000, 3333, 5000, 10000 μg/plate. - Vehicle / solvent:
- - Vehicle/solvent used: Dimethyl Sulfoxide.
Controls
- Untreated negative controls:
- no
- Negative solvent / vehicle controls:
- yes
- Remarks:
- Dimethyl Sulfoxide.
- Positive controls:
- yes
- Positive control substance:
- sodium azide
- other: 2-aminoanthracene, 4-nitro-o-phenylenediamine.
- Remarks:
- (sodium azide: without metabolic activation; 2-aminoanthracene, 4-nitro-o-phenylenediamine: with metabolic activation).
- Details on test system and experimental conditions:
- METHOD OF APPLICATION: preincubation method.
DURATION
- Preincubation period: 20 minutes at 37 ºC.
Results and discussion
Test resultsopen allclose all
- Species / strain:
- S. typhimurium, other: S. typhimurium TA 100, TA 1535 and TA 98.
- Metabolic activation:
- without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- cytotoxicity
- Remarks:
- (slightly toxicity at ≥ 10000 µg/plate)
- Vehicle controls validity:
- valid
- Untreated negative controls validity:
- not applicable
- Positive controls validity:
- valid
- Species / strain:
- S. typhimurium, other: S. typhimurium TA 100 and TA 1535.
- Metabolic activation:
- with
- Genotoxicity:
- positive
- Cytotoxicity / choice of top concentrations:
- cytotoxicity
- Remarks:
- (slightly toxicity at ≥ 5000 µg/plate)
- Vehicle controls validity:
- valid
- Untreated negative controls validity:
- not applicable
- Positive controls validity:
- valid
- Species / strain:
- S. typhimurium TA 98
- Metabolic activation:
- with
- Genotoxicity:
- ambiguous
- Cytotoxicity / choice of top concentrations:
- cytotoxicity
- Remarks:
- (slightly toxicity at ≥ 5000 µg/plate)
- Vehicle controls validity:
- valid
- Untreated negative controls validity:
- not applicable
- Positive controls validity:
- valid
- Remarks on result:
- other: all strains/cell types tested
- Remarks:
- Migrated from field 'Test system'.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
positive with metabolic activation (induced male Syrian hamster liver S9).
The test substance is considered to be genotoxic in vitro. - Executive summary:
A standard NTP (National Toxicology Program) protocol was performed to investigate the mutagenicity of 2-vinylpyridine (test method equivalent to OECD 471). Different concentrations of the test substance were tested in Salmonella typhimurium strains TA 100, TA 1535 and TA 98 by the preincubation assay (37 ºC, 20 min) with and without metabolic activation (induced male Syrian hamster liver S9 mix and induced male SD rat liver S9 mix). Positive and negative controls confirmed the sensitivity of the test system. In the presence of exogenous metabolic activation, Salmonella strains TA 100 and TA 1535 gave positive results, while S. typhimurium TA 98 gave ambiguous results. Slightly toxicity was found at concentrations of 5000 µg/plate and above. From the results of the present study, the test substance is considered to be genotoxic in vitro.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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