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Diss Factsheets
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EC number: 202-443-7 | CAS number: 95-71-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to microorganisms
Administrative data
- Endpoint:
- toxicity to microorganisms
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Scientifically acceptable publication
Data source
Reference
- Reference Type:
- publication
- Title:
- Biological effects of prenylated hydroquinones: structure-activity relationship studies in antimicrobial, brine shrimp, and fish lethality assays
- Author:
- De Rosa, S., De Giuli,o A. and Iodice, C.
- Year:
- 1 994
- Bibliographic source:
- Journal of Natural Products 57(12): 1711-1716, 1994
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- A test guideline was not mentioned in the publication.
- GLP compliance:
- no
Test material
- Reference substance name:
- 2-methylhydroquinone
- EC Number:
- 202-443-7
- EC Name:
- 2-methylhydroquinone
- Cas Number:
- 95-71-6
- Molecular formula:
- C7H8O2
- IUPAC Name:
- 2-methylbenzene-1,4-diol
- Reference substance name:
- Methylhydroquinone
- IUPAC Name:
- Methylhydroquinone
- Details on test material:
- - Origin of test material: Sigma-Aldrich s.r.l., Italy
- Purity: 100 %
Constituent 1
Constituent 2
Sampling and analysis
- Analytical monitoring:
- not specified
Test solutions
- Vehicle:
- not specified
Test organisms
- Test organisms (species):
- other: Bacillus subtilis and Micrococcus luteus
- Details on inoculum:
- - Strains: Bacillus subtilis DSM 347 and Micrococcus luteus DSM 348 (both Gram-positive bacteria)
- Origin of microorganisms: DSM, Germany
Study design
- Test type:
- other: diffusion tests on paper disks
- Water media type:
- not specified
- Limit test:
- no
- Total exposure duration:
- 18 h
Test conditions
- Test temperature:
- 35 - 37°C
- Nominal and measured concentrations:
- Two-fold serial dilutions were tested, starting from a 50 µg/mL solution.
- Details on test conditions:
- Preliminary results for antibacterial and antifungal activities were obtained by means of diffusion tests, using 100 mg of compound per paper disk (6 mm). The impregnated disks were applied on nutrient agar plates, seeded with overnight cultures of the test microorganisms. The inhibition zones were measured after 18 h incubation at 35-37° C. Quantitacive measurement on active compounds, selected by means of the diffusion test, were performed to determine the minimum inhibitory concentration (MIC). The end point in this assay was indicated by thr absence of detectable growth after 18 h of incubation.
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 18 h
- Dose descriptor:
- other: MIC
- Effect conc.:
- 25 mg/L
- Remarks on result:
- other: Bacillus subtilis
- Duration:
- 18 h
- Dose descriptor:
- other: MIC
- Effect conc.:
- > 50 mg/L
- Remarks on result:
- other: Micrococcus luteus
- Details on results:
- MIC: minimum inhibitory concentration
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.