Lead dioxide

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Well-documented and corresponded to the requirements of the recommended Annex V Test Guidelines

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1992

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

GLP compliance:

not specified

Test type:

acute toxic class method

Test material

Test material information

Constituent 1

Reference substance name:

Trilead bis(carbonate) dihydroxide

EC Number:

215-290-6

EC Name:

Trilead bis(carbonate) dihydroxide

Cas Number:

1319-46-6

Molecular formula:

C2H2O8Pb3

Test material form:

solid: particulate/powder

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

male/female

Details on test animals or test system and environmental conditions:

Source: Forschungsinstitut fur Versuchstierzucht, A-2325 Himberg
Age at study initiation: approx. 8 weeks at time of administration
Acclimation period: 6 days

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

arachis oil

Details on oral exposure:

Maximum dose volume applied: 10 ml per kg body weight

Doses:

"NAFTOVIN T2" was administered once perorally to 5 male and 5 female Him:OFA rats. The test substance, suspended in Arachis oil, was applied once at a dose of 2000 mg per kg body weight by stomach intubation.

No. of animals per sex per dose:

5 male and 5 female

Statistics:

- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Behavior, reactions and physical signs of the animals were observed 10, 30 min, 1, 2, 4 and 6 hours after administration (p.a.) and then at least once a day for a total of 2 weeks. Body weight was determined before administration, 7 days p.a. and 14 days p.a.
- Necropsy of survivors performed: yes

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 2 000 mg/kg bw

Mortality:

None.

Clinical signs:

All animals were normal during the whole study. No toxic signs were noted.

Body weight:

Body weight gain of the animals was inconspicuous.

Other findings:

No sex differences between males and females were noted in the response to the test substance.

Applicant's summary and conclusion

Interpretation of results:

other: practically nontoxic

Remarks:

Migrated information The LD50 for both male and female rats is higher than 2000 mg/kg of lead basic carbonate. Criteria used for interpretation of results: other: OECD-Guideline 401, "Acute Oral Toxicity, Limit-Test," 1987

Executive summary:

The observations in life revealed no toxic signs. 9/10 animals were normal at post mortem examination. Alterations of the 10th rat are not attributed to the action of the test substance, as similar changes are known to occur spontaneously with a low incidence in untreated rats of the strain used, and due to the single occurence in this study. No differences between the sexes were noted in the response to the test substance. All animals survived until termination. Therefore, LD50 (oral) for both male and female rats is higher than 2000 mg lead basic carbonate per kg body weight.