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EC number: 935-853-6 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
- Endpoint:
- water solubility
- Type of information:
- calculation (if not (Q)SAR)
- Remarks:
- Migrated phrase: estimated by calculation
- Adequacy of study:
- key study
- Study period:
- Between 04 June 2009 and 17 August 2009
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study conducted in accordance with generally accepted scientific principles, possibly with incomplete reporting or methodological deficiencies, which do not affect the quality of the relevant results.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 009
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Date of inspection: 19/08/2008 Date of Signature: 04/03/2009
- Type of method:
- flask method
Test material
- Reference substance name:
- Reaction mass of 2-(3-ethylphenyl)oxirane and 2,2’-(1,3-phenylene)dioxirane and 2,2'-(1,4-phenylene)dioxirane
- EC Number:
- 935-853-6
- IUPAC Name:
- Reaction mass of 2-(3-ethylphenyl)oxirane and 2,2’-(1,3-phenylene)dioxirane and 2,2'-(1,4-phenylene)dioxirane
- Reference substance name:
- Reaction mass of bis(epoxyethyl) benzene and (ethylphenyl) oxirane
- IUPAC Name:
- Reaction mass of bis(epoxyethyl) benzene and (ethylphenyl) oxirane
- Details on test material:
- - Name of test material (as cited in study report): Reaction mass of bis(epoxyethyl) benzene and (ethylphenyl) oxirane
- Substance type: Multiconstituent
- Physical state: clear extremely pale yellow liquid
- Analytical purity: 80 - 95%
- Lot/batch No.: 200901317-17
- Stability under test conditions : undergoes hydrolysis
- Storage condition of test material : approximately 4°C in the dark
Constituent 1
Constituent 2
Results and discussion
Water solubility
- Water solubility:
- >= 0.264 - <= 2.76 g/L
- Temp.:
- 20 °C
- pH:
- >= 7.2 - <= 7.6
- Details on results:
- Therefore, a short-term test was performed, which limited the generation of hydrolysis products in the sample solutions and also resulted in approximate saturation plateaux for all components monitored. Based on the high degree of hydrolysis evident in the definitive test and the resulting solubility trends observed, the short-term results have been taken as the overall conclusive result for the test.
The general trend was for the analysed concentration of peak 1 to decrease with time (1.77 to 0.953 g/l on analysis), peak 2 increased with time (0.603 to 2.03 g/l) and peak 3 showed no significant trend, although a reduced concentration (0.104 to 0.172 g/l) was detected on analysis.
Any other information on results incl. tables
Results:
Preliminary Test:
The preliminary estimate of water solubility was equivalent to 2.36 g/l of test material for peak 1, equivalent to 0.397 g/l of test material for peak 2 and equivalent to 0.172 g/l of test material for peak 3.
Definitive Test:
The mean peak areas relating to the standard and sample solutions are shown in the following tables:
Table 1– Peak 1
Solution |
MeanArea |
Standard 157 mg/l |
4.645 x 103 |
Standard 174 mg/l |
5.126 x 103 |
Matrix blank |
none detected |
Sample 1A |
2.648 x 103 |
Sample 1B |
2.587 x 103 |
Sample 2A |
2.279 x 103 |
Sample 2B |
2.301 x 103 |
Sample 3A |
1.399 x 103 |
Sample 3B |
1.413 x 103 |
Table 2.– Peak 2
Solution |
MeanArea |
Standard 15.7 mg/l |
15.808 |
Standard 17.4 mg/l |
16.544 |
Matrix blank |
none detected |
Sample 1A |
29.851 |
Sample 1B |
29.158 |
Sample 2A |
68.908 |
Sample 2B |
70.897 |
Sample 3A |
99.035 |
Sample 3B |
99.339 |
Table 3– Peak 3
Solution |
MeanArea |
Standard 15.7 mg/l |
78.956 |
Standard 17.4 mg/l |
84.212 |
Matrix blank |
none detected |
Sample 1A |
33.961 |
Sample 1B |
32.852 |
Sample 2A |
42.426 |
Sample 2B |
42.671 |
Sample 3A |
26.014 |
Sample 3B |
25.538 |
The equivalent concentration (g/l) of test material in the sample solutions is shown in the following tables:
Table 4– Peak 1
Sample Number |
Time Shaken at ~ 30ºC (hours) |
Time Equilibrated at 20ºC (hours) |
Concentration (g/l) |
Solution pH |
1 |
24 |
24 |
1.77 |
7.3 |
2 |
48 |
24 |
1.55 |
6.8 |
3 |
72 |
24 |
0.953 |
6.6 |
Range: 1.77 to 0.953 g/l
Table 5– Peak 2
Sample Number |
Time Shaken at ~ 30ºC (hours) |
Time Equilibrated at 20ºC (hours) |
Concentration (g/l) |
Solution pH |
1 |
24 |
24 |
0.603 |
7.3 |
2 |
48 |
24 |
1.43 |
6.8 |
3 |
72 |
24 |
2.03 |
6.6 |
Range: 0.603 to 2.03 g/l
Table 6– Peak 3
Sample Number |
Time Shaken at ~ 30ºC (hours) |
Time Equilibrated at 20ºC (hours) |
Concentration (g/l) |
Solution pH |
1 |
24 |
24 |
0.135 |
7.3 |
2 |
48 |
24 |
0.172 |
6.8 |
3 |
72 |
24 |
0.104 |
6.6 |
Range: 0.104 to 0.172 g/l
Short-term test
The mean peak areas relating to the standard and sample solutions are shown in the following tables:
Table 7– Peak 1
Solution |
MeanArea |
Standard 150 mg/l |
4.273 x 103 |
Standard 151 mg/l |
4.285 x 103 |
Matrix blank |
none detected |
Sample 4A |
3.868 x 103 |
Sample 4B |
3.850 x 103 |
Sample 5A |
3.989 x 103 |
Sample 5B |
3.972 x 103 |
Sample 6A |
3.924 x 103 |
Sample 6B |
3.936 x 103 |
Table 8– Peak 2
Solution |
MeanArea |
Standard 15.0 mg/l |
14.790 |
Standard 15.1 mg/l |
14.610 |
Matrix blank |
none detected |
Sample 4A |
25.418 |
Sample 4B |
25.399 |
Sample 5A |
28.522 |
Sample 5B |
29.524 |
Sample 6A |
27.728 |
Sample 6B |
27.594 |
Table 9– Peak 3
Solution |
MeanArea |
Standard 15.0 mg/l |
74.247 |
Standard 15.1 mg/l |
73.727 |
Matrix blank |
none detected |
Sample 4A |
60.962 |
Sample 4B |
60.373 |
Sample 5A |
70.497 |
Sample 5B |
70.516 |
Sample 6A |
63.769 |
Sample 6B |
64.022 |
The equivalent concentration (g/l) of test material in the sample solutions is shown in the following tables:
Table 10– Peak 1
Sample Number |
Time Shaken at ~ 30ºC (hours) |
Time Equilibrated at 20ºC (hours) |
Concentration (g/l) |
Solution pH |
4 |
1 |
1 |
2.71 |
7.2 |
5 |
2 |
1 |
2.80 |
7.6 |
6 |
3 |
1 |
2.76 |
7.5 |
Mean concentration:2.76 g/l at 20.0 ± 0.5ºC
Range: 2.71 to 2.80 g/l
Table 11– Peak 2
Sample Number |
Time Shaken at ~ 30ºC (hours) |
Time Equilibrated at 20ºC (hours) |
Concentration (g/l) |
Solution pH |
4 |
1 |
1 |
0.520 |
7.2 |
5 |
2 |
1 |
0.594 |
7.6 |
6 |
3 |
1 |
0.566 |
7.5 |
Mean concentration:0.560 g/l at 20.0 ± 0.5ºC
Range: 0.520 to 0.594 g/l
Table 12– Peak 3
Sample Number |
Time Shaken at ~ 30ºC (hours) |
Time Equilibrated at 20ºC (hours) |
Concentration (g/l) |
Solution pH |
4 |
1 |
1 |
0.247 |
7.2 |
5 |
2 |
1 |
0.287 |
7.6 |
6 |
3 |
1 |
0.260 |
7.5 |
Mean concentration:0.264 g/l at 20.0 ± 0.5ºC
Range: 0.247 to 0.287 g/l
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): other: Under standard test conditions as detailed in Method A6, significantly different sample concentrations were achieved; attributed to the influence of hydrolysis.
Under standard test conditions as detailed in Method A6, significantly different sample concentrations were achieved; attributed to the influence of hydrolysis. The general trend was for the analysed concentration of peak 1 to decrease with time (1.77 to 0.953 g/l on analysis), peak 2 increased with time (0.603 to 2.03 g/l) and peak 3 showed no significant trend, although a reduced concentration (0.104 to 0.172 g/l) was detected on analysis. - Executive summary:
- The water solubility of the test material was
determined at 20.0 ± 0.5°C, using a flaskthod, based on Method A6 Water
Solubility of Commission Regulation (EC) No 440/2008 of 30 May 2008. The
results are summarised in the following table:
Peak
Attributed to:
Equivalent Test Material Concentration
(g/l of solution at 20.0 ± 0.5°C)1
2 x bis(epoxyethyl) benzene components
2.76
2
(ethylphenyl) oxirane component
0.560
3
(ethylphenyl) oxirane component
0.264
However these sample concentrations were achieved only on significantly reducing the saturation and equilibration periods for the procedure, i.e. a short-term test. Under standard test conditions as detailed in Method A6, significantly different sample concentrations were achieved; attributed to the influence of hydrolysis. The general trend was for the analysed concentration of peak 1 to decrease with time (1.77 to 0.953 g/l on analysis), peak 2 increased with time (0.603 to 2.03 g/l) and peak 3 showed no significant trend, although a reduced concentration (0.104 to 0.172 g/l) was detected on analysis.
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