Registration Dossier
Registration Dossier
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EC number: 700-676-3 | CAS number: 135452-42-5
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Test was conducted according to OECD 423 and compliant with GLP. Read-across from supporting substance (structure analogue or surrogate). Test substance (source substance): CAS No. 135452-43-6
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 013
- Report date:
- 2013
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
Test material
- Reference substance name:
- 2-hydroxy-1-{1-[4-(2-hydroxy-2-methylpropanoyl)phenyl]-1,3,3-trimethyl-2,3-dihydro-1H-inden-5-yl}-2-methylpropan-1-one
- IUPAC Name:
- 2-hydroxy-1-{1-[4-(2-hydroxy-2-methylpropanoyl)phenyl]-1,3,3-trimethyl-2,3-dihydro-1H-inden-5-yl}-2-methylpropan-1-one
- Reference substance name:
- 135452-43-6
- Cas Number:
- 135452-43-6
- IUPAC Name:
- 135452-43-6
- Reference substance name:
- 1-Propanone, 1-[2,3-dihydro-1-[4-(2-hydroxy-2-methyl-1-oxopropyl)phenyl]-1,3,3-trimethyl-1H-inden-5-yl]-2-hydroxy-2-methyl-
- IUPAC Name:
- 1-Propanone, 1-[2,3-dihydro-1-[4-(2-hydroxy-2-methyl-1-oxopropyl)phenyl]-1,3,3-trimethyl-1H-inden-5-yl]-2-hydroxy-2-methyl-
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
Constituent 1
Constituent 2
Constituent 3
Test animals
- Species:
- rat
- Strain:
- other: Crl: CD (SD)
- Sex:
- female
Administration / exposure
- Route of administration:
- oral: gavage
- Doses:
- Six female animals were dosed with 2000 mg/kg test item by oral gavage in a dose volume of 20 mL/kg.
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality occured during study period (Day 1 to Day 14).
- Clinical signs:
- other: Hunched posture and piloerectiin were observed in some animals within 4 hours after dosing.Light-brown feces ware observed in all animals an day 2. No clinical signs were observed from day3 till to the end of study.
- Gross pathology:
- No gross lesion was found in all animals.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The test substance has a LD50 > 2000 mg/kg bw and is not classified via the oral route in rats.
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