Registration Dossier
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EC number: 248-096-5 | CAS number: 26896-48-0
Toxicity to soil macroorganisms except arthropods
Administrative data
Link to relevant study record(s)
Description of key information
(No)effect concentrations determined in a valid Earthworm Reprodution Test (OECD 222):
NOEC (reproduction, 56 d) = 59 mg/kg soil dw (nominal)
EC10 (reproduction, 56 d) = 39 mg/kg soil dw (nominal)
Key value for chemical safety assessment
- Long-term EC10, LC10 or NOEC for soil macroorganisms:
- 39 mg/kg soil dw
Additional information
An Earthworm Reproduction Test according to OECD 222 was performed with the test item (compliant with GLP). The study was performed using eight concentrations ranging from 1000 to 59 mg/kg dry soil.
No relevant mortality of adult animals after 28 days was observed, neither for the controls, nor for the treatment groups.
All surviving adult animals showed normal behaviour. Morphology of the surviving adult animals was normal. No relevant deviations of fresh weight change of surviving adults were observed for the treatment replicates compared to blank and solvent controls.
Inhibition of reproduction in the treatments in comparison to the combined controls was ob-served, ranging from 9.6 % to 80 %. All treatments except the lowest showed statistically significant inhibition of reproduction. All validity criteria were met.
The following results were obtained:
NOEC (reproduction, 56 d) = 59 mg/kg soil dw (nominal)
LOEC (reproduction, 56 d) = 88 mg/kg soil dw (nominal)
EC10 (reproduction, 56 d) = 39 mg/kg soil dw (nominal), 95% CI: 14 - 107.
The NOEC equals the lowest concentration applied, such that the EC10 is an extrapolated value. Nonetheless, as it is close to the lowest test item concentration applied and based on a sound concentration-effect relationship, the EC10 is regarded to be most relevant for chemical safety assessment.
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