Registration Dossier
Registration Dossier
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EC number: 610-950-3 | CAS number: 53056-20-5
Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP study according to OCED/EU guideline
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 009
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- shake-flask method to: flask method
- Partition coefficient type:
- octanol-water
Test material
- Reference substance name:
- 2,4-dichlorophenylacetic acid
- EC Number:
- 243-248-7
- EC Name:
- 2,4-dichlorophenylacetic acid
- Cas Number:
- 19719-28-9
- Molecular formula:
- C8H6Cl2O2
- IUPAC Name:
- (2,4-dichlorophenyl)acetic acid
Constituent 1
Results and discussion
Partition coefficientopen allclose all
- Type:
- Pow
- Partition coefficient:
- 682
- Temp.:
- 23 °C
- pH:
- 2
- Type:
- log Pow
- Partition coefficient:
- 2.8
- Temp.:
- 23 °C
- pH:
- 2
- Type:
- Pow
- Partition coefficient:
- 20.3
- Temp.:
- 23 °C
- pH:
- 5.7
- Type:
- log Pow
- Partition coefficient:
- 1.3
- Temp.:
- 23 °C
- pH:
- 5.7
- Type:
- Pow
- Partition coefficient:
- 0.53
- Temp.:
- 23 °C
- pH:
- 7
- Type:
- log Pow
- Partition coefficient:
- -0.3
- Temp.:
- 23 °C
- pH:
- 7
Any other information on results incl. tables
The partition coefficients 1-octanol /water of the test item in distilled water, at pH 2 and at pH 7 at room temperature (23°C) were
determined according to the "shake flask method" described in EEC Test Guideline 92/69, A.8., OECD Test Guideline 107 and EPA Product Properties Test Guideline OPPTS 830.7550.
The concentrations of the test item in the 1 -octanol phases and in the aqueous phases were quantified by HPLC analyses.
The used HPLC method (reversed phase) was validated and found to be valid.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
