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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
abstract
Justification for type of information:
Data is from abstratct of publication

Data source

Reference
Reference Type:
publication
Title:
Toxicity and hygienic standardization of isophorone, dihydroisophorone, and dimethylphenylcarbinol
Author:
Bukhalovskii, A. A.; Shugaev, B. B.
Year:
1976
Bibliographic source:
Promyshlennost Sinteticheskogo Kauchuka (1976), (2), 4-5

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other:
Principles of method if other than guideline:
The acute oral LD50 value for the chemical 3,3,5-trimethylcyclohexan-1-one was tested in rats.
GLP compliance:
not specified
Test type:
other: No data

Test material

Constituent 1
Chemical structure
Reference substance name:
3,3,5-trimethylcyclohexan-1-one
EC Number:
212-855-9
EC Name:
3,3,5-trimethylcyclohexan-1-one
Cas Number:
873-94-9
Molecular formula:
C9H16O
IUPAC Name:
3,3,5-trimethylcyclohexan-1-one
Test material form:
liquid
Details on test material:
- Name of test material :3,3,5-trimethylcyclohexan-1-one
- IUPAC name: 3,3,5-Trimethylcyclohexanone
- Molecular formula :C9H16O
- Molecular weight :140.224
- Smiles notation :C1(C[C@@H](CC(C1)=O)C)(C)C
- InChl :1S/C9H16O/c1-7-4-8(10)6-9(2,3)5-7/h7H,4-6H2,1-3H3
- Substance type: Organic
- Physical state: liquid
Specific details on test material used for the study:
- Name of test material :3,3,5-trimethylcyclohexan-1-one
- Molecular formula :C9H16O
- Molecular weight :140.224
- Smiles notation :C1(C[C@@H](CC(C1)=O)C)(C)C
- InChl :1S/C9H16O/c1-7-4-8(10)6-9(2,3)5-7/h7H,4-6H2,1-3H3
- Substance type: Organic
- Physical state: liquid

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
No data

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Details on oral exposure:
No data
Doses:
No data
No. of animals per sex per dose:
No data
Control animals:
not specified
Details on study design:
No data
Statistics:
No data

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
3 800 mg/kg bw
Based on:
test mat.
Remarks on result:
other: No other details available
Mortality:
No data
Clinical signs:
other: The clinical toxic symptoms of the substance was similar to those of narcotics
Gross pathology:
No data
Other findings:
No data

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
The acute oral LD50 value of test chemical 3,3,5- rimethylcyclohexan-1-one is determined to be 3800 mg/Kg in rats.
Executive summary:

The acute oral LD50 value for the chemical 3,3,5-trimethylcyclohexan-1-one was tested in rats. LD50 value was determined to be 3800 mg/Kg with clinical symptoms similar to those of narcotics. Thus based on this value it can be concluded that the substance 3,3,5-trimethylcyclohexan-1-one is not classified in acute oral category as per the criteria of CLP regulation.