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EC number: 701-366-0 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
In the absence of experimental data on the
substance, the potential acute toxicity of F-DIOX potassium salt was
evaluated through the Read Across approach with cC6O4 ammonium salt.
Impurities are considered contributing to the classification of F-DIOX
potassium salt, classification was determined considering the presence
and the concentration of impurities.
Key value for chemical safety assessment
Additional information
F-DIOX potassium salt is an organic carboxylic acid derivative.
In order to evaluate the potential acute toxicity of F- Diox potassium salt it was deemed appropriate to use the Read Across approach based on experimental studies performed on cC6O4 ammonium salt by virtue of similarity of chemical structure between F- Diox potassium salt and cC6O4 ammonium salt (CAS no: 1190931-27-1).
F-DIOX potassium salt and cC6O4 ammonium salt are two salts of the same carboxylic acid, they differ only for the cationic part (K+ in F-DIOX potassium salt and NH4+ in cC6O4 ammonium salt). F-DIOX potassium salt readily dissolves in aqueous media and dissociates to the corresponding carboxylic acid in equilibrium with its anion. The dissociation is expected to be similar for F-DIOX potassium salt and cC6O4 ammonium salt.
Considering the similarity of chemical structure, a similar biological behaviour is expected between the two substances.
An oral toxicity study and a dermal toxicity study were performed on cC6O4 ammonium salt.
The results of the oral toxicity study indicate that cC6O4 ammonium salt has a toxic effect on the rat following oral administration of a single dose at a level of 2000 mg(dry salt)/kg. The mortality pattern demonstrates the LD50 to be greater than 300 mg (dry salt)/kg but less than 2000 mg (dry salt)/kg body weight.
The results of the dermal toxicity study indicate that cC6O4 ammonium salt has no toxic effect on the rat following dermal exposure over a 24 hour period at a level of 2000 mg/kg. The lack of mortality demonstrates the LD50 to be greater than 2000 mg/kg.
Considering the similarity of chemical structure between C6O4 ammonium salt and F-DIOX potassium salt, a similar biological behaviour is expected for the two substances.
In order to apply the classification according to Regulation (EC) No. 1272/2008, the presence of impurities was considered.
Justification for classification or non-classification
Classification of the dry salt:
The classification is based on the Read Across approach with cC6O4 ammonium salt above discussed and taking into account the typical concentration of impurities present in the dried substance.
The hazardous constituents and impurities present and their typical concentration in the dried substance were considered in the classification of the registered substance:
In addition to the main potassium constituent there are two impurities with an acute toxicity classification. Applying the rules of Regulation 1272/2008, only one is above the cut-off for contribution to the classification and needs to be considered, potassium fluoride. For the purpose of the classification of F-Diox Potassium Salt, the harmonised classification of potassium fluoride was taken into account in the calculations, although the registration dossier of the potassium fluoride seems to indicate it is conservative. Thus, the classification of F-Diox Potassium salt is also likely severised.
F-Diox Potassium salt (self-classification, based on data on related ammonium salt)
Acute toxicity - category 4 - H302
Potassium fluoride (Harmonised classification)
Acute oral toxicity - Category 3 - H 301
Acute dermal toxicity - Category 3 - H 311
Acute toxicity inhalation - Category 3 - H 331
Classification of the registered substance:
Applying classification rules of the European CLP Regulation (Council Regulation (EC) No. 1272/2008 and subsequent revisions) and considering the concentrations of hazardous substances present, the registered substance is classified hazardous with the following hazard statements:
Classification : Acute toxicity oral - Category 3
Hazard statement (Oral) : H301, Toxic if swallowed
Classification : Acute toxicity dermal - Category 4
Hazard statement (Dermal) : H312, Harmful in contact with skin
Classification : Acute toxicity inhalation- Category 4
Hazard statement (Inhalation) : H332, Harmful if inhaled
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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