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Diss Factsheets

Administrative data

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
November 23, 1992
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: This study has been performed according to OECD 117 (1989) and according to GLP principles. Limited information available to verify the composition of the used test substance.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1993
Report date:
1993

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
Version / remarks:
(1989)
Deviations:
no
GLP compliance:
yes
Type of method:
HPLC method
Partition coefficient type:
octanol-water

Test material

Constituent 1
Reference substance name:
A mixture of: 2,4 -bis(N'-(4-methylphenyl)ureido)toluene; 2,6 -bis(N'-(4-methylphenyl)ureido)toluene
EC Number:
411-070-0
EC Name:
A mixture of: 2,4 -bis(N'-(4-methylphenyl)ureido)toluene; 2,6 -bis(N'-(4-methylphenyl)ureido)toluene
Molecular formula:
C23H24N4O2
IUPAC Name:
3-(2-methyl-5-{[(4-methylphenyl)carbamoyl]amino}phenyl)-1-(4-methylphenyl)urea
Details on test material:
- Name of test material (as cited in study report): KY-ET
- Appearance: Light yellow solid
- Storage condition of test material: At room temperature in the dark

Study design

Analytical method:
other: HPLC-UV

Results and discussion

Partition coefficientopen allclose all
Type:
log Pow
Partition coefficient:
2.6
Temp.:
22 °C
Remarks on result:
other: For peak 1
Type:
Pow
Partition coefficient:
398
Temp.:
22 °C
Remarks on result:
other: For peak 1
Type:
log Pow
Partition coefficient:
3.1
Temp.:
22 °C
Remarks on result:
other: For peak 2 (main component)
Type:
Pow
Partition coefficient:
1 259
Temp.:
22 °C
Remarks on result:
other: For peak 2 (main component)
Details on results:
- In the HPLC chromatograms of the substance, one large peak and one smaller peak were observed. No peaks were observed after approx. 5.5 minutes.
- The t0 was determined to be 1.17 minutes (mean of 2 measurements: 1.17 an 1.17)
- Linear regression analysis: Slope: 0.337; Intercept: -0.821; Correlation coefficient: 0.988 (n=6)
- No substance related peaks were observed in the HPLC chromatograms of the blank test solution and of the blank

Any other information on results incl. tables

Reference substance

Mean value of the retention times of 2 chromatograms

k’

Log k’

Benzylalcohol (p.a., Merck)

1.47

0.256

-0.592

Toluene (p.a., Merck)

3.09

1.641

0.215

1,4-dichlorobenzene (z.s., Merck)

4.04

2.453

0.390

1,2,4-trichlorobenzene (LiChrosolv, Merck)

6.59

4.632

0.666

Triphenylamine (98%, GC, Aldrich Chemie)

14.02

10.983

1.041

2,4-DDT (99%, HPLC, Riedel de Haën, Seelze, Germany)

20.42

16.453

1.216

Test Substance

 

Peak 1

2.55

1.179

0.072

Peak 2 (main component)

3.06

1.615

0.208

Applicant's summary and conclusion

Conclusions:
The log Kow values for the 2 constituents of KY-ET are 2.6 and 3.1, determined with the HPLC method in accordance with OECD 117 (1989) and according to GLP principles. The log Kow of the main constituent is 3.1.