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EC number: 700-408-5 | CAS number: 103429-90-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1992-07-14 to 1992-07-17
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- The study report is of good quality and the study was conducted to GLP and documented test parameters are based on specific national guidelines, the purity of test substance is not reported and actual test guideline references are not quoted in test report.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 992
- Report date:
- 1992
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- Principles of method if other than guideline:
- The study report states that the methodology used met OECD and EEC guidelines.
- GLP compliance:
- yes
- Remarks:
- The study report contains a statement of Quality Assurance, and a statement of GLP compliance, but no formal GLP certificate issued by a competent authority or other official body was provided.
Test material
- Reference substance name:
- 3-Methoxy-3-methylbutyl acetate
- EC Number:
- 700-408-5
- Cas Number:
- 103429-90-9
- Molecular formula:
- C8H16O3
- IUPAC Name:
- 3-Methoxy-3-methylbutyl acetate
- Details on test material:
- - Name of test material (as cited in study report): MMB-Ac
- Physical state: Liquid
- Lot/batch No.: 32840
- Storage condition of test material: Stored in the dark, under ambient conditions.
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Interfauna UK Limited, Abbots Ripton Road, Wyton, Huntingdon, Cambs, PE17 2DT.
- Weight at study initiation: 3.2-3.5kg
- Housing: Individually in aluminium cages with grid floors beneath which were absorbent paper lined trays
- Diet (e.g. ad libitum): ad libitum Standard Rabbit Diet, supplied by Special Diets Services Limited, 1 Stepfield, Witham, Essex, CM8 3AD,
- Water (e.g. ad libitum): ad libitum tap water
- Acclimation period: 12 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 - 22
- Humidity (%): mean 47
- Air changes (per hr): 15-20
- Photoperiod (hrs dark / hrs light): 12/12
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- 0.5ml
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- 1, 24, 48 and 72 h after patch removal
- Number of animals:
- 3
- Details on study design:
- TEST SITE
- 6cm2 of skin
- Type of wrap if used: Gauze patch, held in place by micropore tape, bound with elastoplast elastic bandage
REMOVAL OF TEST SUBSTANCE
- Skin wiped with water dampened tissue to remove surplus test material
- Time after start of exposure: 4 hours
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 1 hour
- Score:
- ca. 1
- Max. score:
- 1
- Reversibility:
- fully reversible within: 48 Hours
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24 h
- Score:
- ca. 1
- Max. score:
- 1
- Reversibility:
- fully reversible within: 48 hours
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 48 h
- Score:
- ca. 0
- Max. score:
- 1
- Reversibility:
- fully reversible within: 48 hours
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 72 h
- Score:
- ca. 0
- Max. score:
- 0
- Reversibility:
- fully reversible within: 48 hours
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 1 hour
- Score:
- ca. 0
- Max. score:
- 0
- Reversibility:
- other: Not applicable as no edema seen.
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- ca. 0
- Max. score:
- 0
- Reversibility:
- other: Not applicable as no edema seen.
- Irritant / corrosive response data:
- Very slight erythema (score 1) was noted at all test sites at the 1h and 24 h assessments. Full recovery was noted 48 h after patch removal. No oedematous responses were noted at any time during the study.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Although the study concluded that the test material was slightly irritating, when assessed according to Directive 67/548/EEC, the results do not indicate classification as irritating. Criteria used for interpretation of results: EU
- Conclusions:
- MMB-Ac is slightly irritant to rabbit skin.
- Executive summary:
The acute dermal irritation potential of a test material, MMB-Ac, was investigated in 3 New Zealand White rabbits. Very slight erythema (score I) was noted at all test sites at the 1 h and 24 h assessments, with full recovery noted at 4B h after patch removal. MMB-Ac is slightly irritant to rabbit skin.
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