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EC number: 218-056-1 | CAS number: 2043-57-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: OECD 111
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- GLP compliance:
- no
- Remarks:
- performed at a ISO lab with process similar to GLP
Test material
- Reference substance name:
- 1,1,1,2,2,3,3,4,4,5,5,6,6-tridecafluoro-8-iodooctane
- EC Number:
- 218-056-1
- EC Name:
- 1,1,1,2,2,3,3,4,4,5,5,6,6-tridecafluoro-8-iodooctane
- Cas Number:
- 2043-57-4
- Molecular formula:
- C8H4F13I
- IUPAC Name:
- 1,1,1,2,2,3,3,4,4,5,5,6,6-tridecafluoro-8-iodooctane
- Reference substance name:
- Perfluorohexylethyliodide
- IUPAC Name:
- Perfluorohexylethyliodide
- Test material form:
- other: liquid at 22°C
Constituent 1
Constituent 2
- Radiolabelling:
- no
Study design
- Analytical monitoring:
- yes
- Buffers:
- Buffer solutions:
- Potassium Hydrogen Phthalate buffer pH 4.01: 102.1 g of KHC4H4O6 (supplied by Merck) is added to 2000mL deionised water, agitated and completed with deionised water until 10027g. The solution is effective for 2 years since the preparation. The buffer used in this report was dated from February 18, 2009.
- Phosphate buffer pH 6.86: 33.8g of KH2PO4 (supplied by Merck) and 44.3g of Na2HPO4*H2O (supplied by Merck) were added to 2000mL of deionised water, agitated and completed with deionised water until 10038g. The solution is effective for 1 year since the preparation. The buffer used in this report was dated from March 18, 2010.
- Borax buffer pH 9.18: 38.14g of NaB4O7*10H2O (supplied by Merck) was added to 2000mL of deionised water, agitated and completed with water until 10000g. The solution is effective for 2 years since the preparation. The buffer used in this report was dated from January 26, 2010.
Duration of testopen allclose all
- Duration:
- 5 d
- pH:
- 4
- Temp.:
- 50
- Initial conc. measured:
- 118.7 mg/L
- Duration:
- 5 d
- pH:
- 7
- Temp.:
- 50
- Initial conc. measured:
- 118.7 mg/L
- Duration:
- 5 d
- pH:
- 9
- Temp.:
- 50
- Initial conc. measured:
- 118.7 mg/L
Results and discussion
- Preliminary study:
- At the three different pH, after 5 days of incubation at 50 ± 0.5°C, less than 10% of hydrolysis was found in each case. Therefore, according to the criteria given in the guideline 111, no main study was required to conclude that the half-life time of the test substance is superior at 1 year.
- Transformation products:
- not measured
Total recovery of test substance (in %)open allclose all
- % Recovery:
- 96.38 - 99.25
- pH:
- 4
- Temp.:
- 50 °C
- Duration:
- 5 d
- % Recovery:
- 92.26 - 98.94
- pH:
- 7
- Temp.:
- 50 °C
- Duration:
- 5 d
- % Recovery:
- 93.1 - 99.12
- pH:
- 9
- Temp.:
- 50 °C
- Duration:
- 5 d
Dissipation DT50 of parent compoundopen allclose all
- pH:
- 4
- Temp.:
- 50 °C
- DT50:
- > 1 yr
- pH:
- 7
- Temp.:
- 50 °C
- DT50:
- > 1 yr
- pH:
- 9
- Temp.:
- 50 °C
- DT50:
- > 1 yr
Any other information on results incl. tables
8.RESULTS
8.1Preliminary test
Results of the preliminary test of perfluorohexylethyliodide at pH 4.0, 7.0 and 9.0 at 50°C were performed; the values given in the following table were measured:
Fraction | Initial amount of product introduced | Volume of water sample after 5 days incubation (V1) | Volume of MED sample after extraction and concentration (V2) | Amount in MED measured in GC (c2) |
---|---|---|---|---|
mg/L | mL | mL | mg/L | |
pH 4.0 | 118.7 | 98.20 | 3.6 | 4.18 |
pH 7.0 | 118.7 | 98.97 | 3.4 | 4.36 |
pH 9.0 | 118.7 | 98.90 | 2.8 | 5.08 |
Concentration in water (c1) was calculated using the enrichment factor (volume of solution in dichloromethane (V2) divided by volume of aqueous sample (V1)) and the dilution factor (f). The recovery rate was between 95 and 105% and so, do not take in account. So, the formula used was: c1=c2* (V2/V1)*f
The following table resumes the results found:
Fraction | Initial amount of product introduced (correspond to 100%) | Dilution factor (f) | Amount in water after 5 days incubation (c1) | Hydrolysis percentage after 5 days incubation |
mg/L | mg/L | % | ||
pH 4.0 | 118.7 | 1000 | 117.8 | 0.75 |
pH 7.0 | 118.7 | 1000 | 115.2 | 2.95 |
pH 9.0 | 118.7 | 1000 | 110.6 | 6.90 |
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- Less than 10% of hydrolysis was found after 5 days of incubation at 50°C +/- 0.5°C and for the three different pHs envisaged . According to OECD guideline 111, the test subtance can therefore be considered as hydrolytically stable with a half-life time superior than one year. No further testing is required.
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