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Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
OECD Guideline 123 (Partition Coefficient (1-Octanol / Water), Slow-Stirring Method)
Deviations:
no
GLP compliance:
yes (incl. certificate)
Type of method:
other: Slow Stirring Method
Partition coefficient type:
octanol-water
Analytical method:
gas chromatography
Key result
Type:
log Pow
Partition coefficient:
5.4
Temp.:
25 °C
Remarks on result:
other: Variance weighted standard deviation: 7.98 x 10^-3
Conclusions:
The log10 Pow was determined to be 5.40 using the slow-stir method
Executive summary:

The partition coefficient (log10 Pow) of (ethoxymethoxy)cyclododecane has been determined at a test temperature of 25.0 ± 0.5 °C, using the slow-stir method, OECD TG 123.

A stock solution of test item was prepared in water saturated n-octanol at a concentration 24 g/L. In three individual vessels, 60 mL of this stock solution was then “slow stirred” with 600 mL of n-octanol saturated water. Sampling was initiated from Vessel 1 only, to act as a pilot test vessel to indicate the time required for equilibrium to be achieved. Once this was confirmed, sampling was then performed from all three test vessels. The concentration of test item in the sample solutions was determined by gas chromatography.

The results for the three individual vessels are shown in the following table:

Vessel

A

B

C

Mean Log10Pow

5.38

5.42

5.40

Standard Deviation

2.68 x 10-2

4.50 x 10-2

1.51 x 10-2

Variance

7.20 x 10-4

2.03 x 10-3

2.27 x 10-4

The weighted average log10 Pow is 5.40 and the variance weighted standard deviation is 7.98 x 10^-3.

Description of key information

log Pow = 5.4 at 25 °C

Key value for chemical safety assessment

Log Kow (Log Pow):
5.4
at the temperature of:
25 °C

Additional information

The log Pow was determined to be 5.4 using the slow-stir method in accordance with OECD TG 123.