2-ethoxyethylamine

Skin irritation / corrosion

Administrative data

Endpoint:

skin irritation: in vivo

Type of information:

experimental study

Adequacy of study:

key study

Study period:

24. Apr 1978 - 01. Jun 1978

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Acceptable well documented report which meets basic scientific principles.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1979

Report date:

1979

Materials and methods

Principles of method if other than guideline:

BASF-Test. Two animals were treated for 3 min or 1 h using occlusive conditions. An application site of 1x1 cm was covered with the liquid test substance. After the application time the skin was washed with water and water/Lutrol (1:1). The animals were observed for 8 days and skin changes were recorded daily.

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

2-ethoxyethylamine

EC Number:

203-801-5

EC Name:

2-ethoxyethylamine

Cas Number:

110-76-9

Molecular formula:

C4H11NO

IUPAC Name:

2-ethoxyethylamine

Details on test material:

- Name of test material (as cited in study report): 2-Aethoxyaethylamin
- Analytical purity: 98 %

Test animals

Species:

rabbit

Strain:

Vienna White

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Weight at study initiation: 2.74 kg (mean)

Test system

Type of coverage:

occlusive

Preparation of test site:

not specified

Vehicle:

unchanged (no vehicle)

Controls:

no

Duration of treatment / exposure:

3 min, 1 h

Observation period:

8 days

Number of animals:

2

Details on study design:

TEST SITE
- Area of exposure: 1x1 cm


REMOVAL OF TEST SUBSTANCE
- Washing (if done): concentrated Lutrol and 50% Lutrol
- Time after start of exposure: 3 min and 1 h

Results and discussion

In vivo

Results

Results 1

Irritation parameter:

erythema score

Remarks:

3 min exposure

Basis:

mean

Time point:

other: 24 h - 48 h - 72 h

Score:

4

Max. score:

4

Reversibility:

not fully reversible within: 8 days

Remarks on result:

other: data for the 72h time point was not recorded.

Results 2

Irritation parameter:

edema score

Remarks:

3 min exposure

Basis:

mean

Time point:

other: 24 h - 48 h - 72 h

Score:

2

Max. score:

4

Reversibility:

not fully reversible within: 8 days

Remarks on result:

other: data for the 72h time point was not recorded.

Results 3

Irritation parameter:

erythema score

Remarks:

1 h exposure

Basis:

mean

Time point:

other: 24 h - 48 h - 72 h

Score:

4

Max. score:

4

Reversibility:

not fully reversible within: 8 days

Remarks on result:

other: data for the 72h time point was not recorded.

Results 4

Irritation parameter:

edema score

Remarks:

1 h exposure

Basis:

mean

Time point:

other: 24 h - 48 h - 72 h

Score:

3

Max. score:

4

Reversibility:

not fully reversible within: 8 days

Remarks on result:

other: data for the 72h time point was not recorded.

Any other information on results incl. tables

Mean edema and erythema score from the 3 min and 1 h exposure after 3 min, 1 h, 24 h, 48 h and 8 days (animal1/animal2). Data for the 72 h time point was not recorded.

	3 min		1 h		24 h		48 h		8 days
Exposure	edema	erythema	edema	erythema	edema	erythema	edema	erythema	edema	erythema
3 min exposure	2/2	4/4	-	-	2/2	4/4	2/2	4/4	2/2	4/4
1 h exposure	-	-	2/2	4/4	3/2	4/4	3/2	4/4	3/2	4/4

The test substance caused full thickness necrosis after 3 min of exposure. Full thickness necrosis is considered to be an irreversible effect.