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EC number: 939-526-9 | CAS number: 90506-73-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
Description of key information
The substance has a low potential for bioaccumulation.
Key value for chemical safety assessment
Additional information
According to Reach regulation, Annex IX, Column 2 the study does not need to be conducted as the substance has a low potential for bioaccumulation (log Kow =2.5).
However, data on bioaccumulation are available for the read-across source substance Dibutyl phosphate. The read-across approach is justified based on structural similarity, similar log Kow and similar metabolism.
The log Kow of Dibutyl phosphate predicted by ACD/Labs and EPISuite are 2.451 and 2.29, respectively (http://www.chemspider.com/Chemical-Structure.7593.html); the log Kow of the registered substance is 2.5.
Phosphoric acid alkyl esters are hydrolysed unspecifically to Phosphoric acid and the respective alcohol by phosphatases, e.g. Acid phosphatase or Alkaline phosphatase. Both enzymes are found in most organisms from bacteria to human. The difference in chain length is not considered relevant for the assessment of bioaccumulation potential. After hydrolysis, the respective alcohol moieties are oxidised to the corresponding carboxylic acid which will enter the normal carboxylic acid metabilism.
Phosphate as such is not metabolised. It “is an essential dietary constituent, involved in numerous physiological processes, such as the cell’s energy cycle (high-energy pyrophosphate bonds in adenosine triphosphate [ATP]), regulation of the whole body acid-base balance, as component of the cell structure (as phospholipids) and of nucleotides and nucleic acids in DNA and RNA, in cell regulation and signalling by phosphorylation of catalytic proteins and as second messenger (cAMP).” (EFSA, 2005; available via internet:http://www.efsa.europa.eu/en/efsajournal/doc/233.pdf).
Bioaccumulation of the read-across substance Dibutyl phosphate was tested according to OECD 305C (1981) and Japanese "Method for Testing the Degree of Accumulation of Chemical Substances in Fish Body" stipulated in the "Testing Methods for New Chemical Substances" (July 13, 1974) with the fish Cyprinus carpio. Two concentrations (2 mg/L, 0.2 mg/L) were tested for 6 weeks in a flow through method. The BCF was calculated as quotient of water concentration and concentration in whole fish (homogenised).
The BCF for Dibutyl phosphate was determined to be ≤0.7 (water concentration 2 mg/L) resp. ≤6.9 (water concentration 0.2 mg/L).
A preceeding semistatic acute toxicity test with the fish Oryzias latipes for 48 h resulted in a 48h LC50 of > 250 mg/L. The substance was stable under storage and test conditions.Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.