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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Developmental toxicity / teratogenicity

Currently viewing:

Administrative data

Endpoint:
developmental toxicity
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: see 'Remark'
Remarks:
The substance CAS 15968-01-1 (disodium phthalate) is the sodium salt of the phthalic acid CAS 88-99-3. The main assumption is that sodium is not significant in respect of all the properties under consideration. In dilute aqueous conditions of defined pH a salt will behave no differently to the parent acid, at identical concentration of the particular speciated form present and will be fully dissociated. Therefore, the results obtained with the substance CAS 88-99-3 can be used for the read-across approach.

Data source

Reference
Reference Type:
other: read-across
Title:
Unnamed
Year:
2012

Materials and methods

Principles of method if other than guideline:
Read-across approach from data on an analogue.
GLP compliance:
not specified

Test material

Constituent 1
Reference substance name:
Phthalic acid
EC Number:
201-873-2
EC Name:
Phthalic acid
Cas Number:
88-99-3
IUPAC Name:
phthalic acid
Details on test material:
- Molecular formula (if other than submission substance): C8H6O4
- Molecular weight (if other than submission substance): 166.1308
- Smiles notation (if other than submission substance): OC(=O)c1ccccc1C(=O)O
- InChl (if other than submission substance): InChI=1/C8H6O4/c9-7(10)5-3-1-2-4-6(5)8(11)12/h1-4H,(H,9,10)(H,11,12)
- Structural formula attached as image file (if other than submission substance): see Fig.

Results and discussion

Results: maternal animals

Effect levels (maternal animals)

open allclose all
Dose descriptor:
NOAEL
Effect level:
1 291 mg/kg bw/day
Basis for effect level:
other: maternal toxicity
Dose descriptor:
NOAEL
Effect level:
2 230 mg/kg bw/day
Basis for effect level:
other: developmental toxicity

Results (fetuses)

Fetal abnormalities

Abnormalities:
not specified

Overall developmental toxicity

Developmental effects observed:
not specified

Any other information on results incl. tables

The substance CAS 15968-01-1 (disodium phthalate) is the sodium salt of the phthalic acid CAS 88-99-3. The main assumption is that sodium is not significant in respect of all the properties under consideration. Therefore, the results obtained with the substance CAS 88-99-3 can be used for the read-across approach.

As indicated in the European Chemical Agency Practical Guide 6 “How to report read –across and categories”, the structural grouping was realized using “OECD QSAR APPLICATION TOOL BOX” (see attachment).

Table 1: Data Matrix, Analogue Approach

CAS Number

 

88-99-3

 

15968-01-1

 

CHEMICAL NAME

 

Analogue

Phthalic acid

 

Target chemical

Disodium phthalate

PHYSICO-CHEMICAL DATA

Melting Point

Experimental results:

230 ºC

Experimental results:

No evidence of melting point below 400 ºC.

Decompositionin the range of 450 to 500 °C.

 

Boiling Point

Experimental results:

Decomposes

 

No determination of boiling point is required since there was no evidence of melting below 400 ºC.

 

Density

Experimental results:

1.593 g/cm3 at 15 ºC

Experimental results:

1.67 at 20.8 ºC

 

Vapour Pressure

Experimental results:

8.48 x 10-5 Pa at 25 ºC

Experimental results:

< 3.9 x 10 -5 Pa at 25 ºC

 

Partition Coefficient (log Kow)

Experimental results:

0.73

 

Experimental results:

-2.34 at 20.1 ºC (pH 5.5)

 

Water solubility

 

Experimental results:

6250-7010 mg/L at 25 ºC

 

Experimental results:

In the range of 45.8 to 47.9% w/w at 20 ºC.

 

ENVIRONMENTAL FATE and PATHWAY

Aerobic Biodegradation

 

Estimated data:

Readily biodegradable (BIOWIN v4.10)

 

Estimated data:

Readily biodegradable (BIOWIN v4.10)

 

Anaerobic Biodegradation

No data

No data

 

ENVIRONMENTAL TOXICITY

Acute Toxicity to Fish

No data

 

No data

 

Acute Toxicity to Aquatic Invertebrates

 

No data

No data

Toxicity to Aquatic Plants

 

No data

No data

MAMMALIAN TOXICITY

Acute Oral

Experimental results:

LD50 = 2530 mg/kg (mouse)

 

Read-across:

LD50 = 3200 mg/kg (mouse)

 

Acute Inhalation

 

No data

No data

Acute Dermal

No data

Experimental results:

LD50 > 2000 mg/kg

 

Skin irritation / Eye irritation

No data

Experimental results:

Not a skin irritant.

Not an eye irritant.

 

Skin sensitisation

No data

Experimental results:

Non-sensitising.

 

Repeated Dose

No data

 

No data

 

 

Genetic Toxicity in vitro

 

Gene mutation in bacteria

 

Experimental results:

Negative

Read-across:

Negative

Chromosomal aberration

 

Experimental results:

Negative

Experimental results:

Negative

Mammalian gene mutation

 

No data

Experimental results:

Negative

Genetic Toxicity in vivo

 

Experimental results:

Negative

Read-across:

Negative

Carcinogenicity

 

No data

 

No data

Reproductive Toxicity:

developmental toxicity

Developmental toxicity:

No evidence of developmental toxicity.

NOAEL, maternal toxicity=

1021 mg/kg bw/day;

NOAEL, developmental toxicity=

1763 mg/kg bw/day

 

Read-across:

No evidence of developmental toxicity.

NOAEL, maternal toxicity= 1291 mg/kg bw/day;

NOAEL, developmental toxicity= 2230 mg/kg bw/day

 

Applicant's summary and conclusion

Conclusions:
Based on experimental data, the read-across approach is applied and the NOAEL for the substance is 1291 mg/kg bw/day (maternal toxicity) and 2230 mg/kg bw/day (developmental toxicity).
Executive summary:

The substance CAS 15968-01-1 (disodium phthalate) is the sodium salt of the phthalic acid CAS 88-99-3. The main assumption is that sodium is not significant in respect of all the properties under consideration. In dilute aqueous conditions of defined pH a salt will behave no differently to the parent acid, at identical concentration of the particular speciated form present and will be fully dissociated. Therefore, the results obtained with the substance CAS 88-99-3 can be used for the read-across approach.

Based on experimental data, the read-across approach is applied and the NOAEL for the substance is 1291 mg/kg bw/day (maternal toxicity) and 2230 mg/kg bw/day (developmental toxicity).