Registration Dossier
Registration Dossier
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EC number: 249-949-4 | CAS number: 29911-27-1
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1989
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Follow GLP guidelines
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 989
- Report date:
- 1989
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EU Method B.52 (Acute Inhalation Toxicity - Acute Toxic Class Method)
- Version / remarks:
- Not specified
- Principles of method if other than guideline:
- Not Specified
- GLP compliance:
- yes
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- 1-(1-methyl-2-propoxyethoxy)propan-2-ol
- EC Number:
- 249-949-4
- EC Name:
- 1-(1-methyl-2-propoxyethoxy)propan-2-ol
- Cas Number:
- 29911-27-1
- Molecular formula:
- C9H20O3
- IUPAC Name:
- 1-(1-methyl-2-propoxyethoxy)propan-2-ol
- Test material form:
- not specified
- Details on test material:
- - Name of test material (as cited in study report):Propyl Dipropasol Solvent
- Substance type: Clear, low viscosity liquid
- Analytical purity: 99%
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Diet (e.g. ad libitum): ad libium
- Water (e.g. ad libitum): ad libitum
- Weight: Between 200 and 300 g
ENVIRONMENTAL CONDITIONS
No information available
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- not specified
- Vehicle:
- not specified
- Details on inhalation exposure:
- Sprague-Dawley albino rats, weighing between 200 and 300 g, are exposed to substantially saturated vapor for 6 hours. The vapor is produced by enclosing approximately 100 g of the test material in a sealed 100 to 151-liter animal chamber for approximately 18 hours (static conditions). A mixing fan periodically agitates the chamber atmosphere to aid in distribution of the vapor. Oxygen is added, as needed, for static exposures to maintain a chamber oxygen content of approximately 20%. If deaths occur, exposure times are varied to determine an LT50. Five males and 5 females are included for each exposure period.
- Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- 6 h
- Concentrations:
- saturated vapor
- No. of animals per sex per dose:
- 5 males and 5 females
- Control animals:
- not specified
- Details on study design:
- Sprague-Dawley albino rats, weighing between 200 and 300 g, are exposed to substantially saturated vapor for 6 hours. The vapor is produced by enclosing approximately 100 g of the test material in a sealed 100 to 151-liter animal chamber for approximately 18 hours (static conditions). A mixing fan periodically agitates the chamber atmosphere to aid in distribution of the vapor. Oxygen is added, as needed, for static exposures to maintain a chamber oxygen content of approximately 20%. If deaths occur, exposure times are varied to determine an LT50. Five males and 5 females are included for each exposure period.
- Statistics:
- Not applicable
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- other: LC50 > Substantially Saturated Vapor (Static)
- Remarks on result:
- other: LC50 > Substantially Saturated Vapor (Static)
- Mortality:
- No Mortality
- Clinical signs:
- other: No signs of toxicity
- Body weight:
- No data
- Gross pathology:
- No remarkable gross lesions were evident
- Other findings:
- No additional data
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- Inhalation, Rat; Substantially Saturated Vapor (Static):
Males: 6.0 hours killed 0 of 5.
Females: 6.0 hours killed 0 of 5. - Executive summary:
Exposure to a statically-generated, substantially saturated vapor produced no deaths of male and female rats during or following the 6-hour test. There were no signs of toxicity evident and no remarkable gross lesions were evident at necropsy.
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