Registration Dossier
Registration Dossier
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EC number: 454-140-6 | CAS number: 376608-71-8
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 004
- Report date:
- 2004
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: OECD 429, OPPTS 870.2600
- GLP compliance:
- yes
- Type of study:
- mouse local lymph node assay (LLNA)
Test material
- Reference substance name:
- -
- EC Number:
- 454-140-6
- EC Name:
- -
- Cas Number:
- 376608-71-8
- Molecular formula:
- C9H9F2N*C8H8O3
- IUPAC Name:
- (1R)-2-(3,4-difluorophenyl)cyclopropan-1-aminium (2R)-2-hydroxy-2-phenylacetate
Constituent 1
In vivo test system
Test animals
- Species:
- mouse
- Strain:
- CBA
- Sex:
- female
Study design: in vivo (non-LLNA)
- No. of animals per dose:
- Number of animals in test group: 4
Number of animals in negative control group: 4
Study design: in vivo (LLNA)
- Vehicle:
- dimethylformamide
Results and discussion
Any other information on results incl. tables
Comments:
Test substance - results and comments
Concentration of test DPM/lymph node Test:control ratio
substance (% w/v)
0 (vehicle control) 425 N/A
0.25 810 1.91
0.5 1879 4.42
1 2625 6.18
Summary of results: C3RO is a skin sensitiser under the
conditions of the test
-----------------------------------------------------------
Positive control substance (hexylcinnamaldehyde) - results
and comments
Concentration of test DPM/lymph node Test:control ratio
substance (% w/v)
0 (vehicle control)* 665 N/A
2.5 921 1.38
5 938 1.41
10 2085 3.14
*4:1 acetone in olive oil
Summary of results: A sensitiser under the conditions of the
test.
Applicant's summary and conclusion
- Interpretation of results:
- sensitising
- Remarks:
- Migrated information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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