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EC number: 207-975-3 | CAS number: 503-74-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
No valid data could be located regarding the short-term toxicity of isovaleric acid to aquatic invertebrates.
To compensate for this lack of data, information resulting from isobutyric acid as supporting substance is used.
Supporting substance isobutyric acid: in a valid Daphnia magna acute immobilization test similar to OECD TG 202, the EC50 of isobutyric acid was determined to be 51.25 mg/L (BASF AG, 1989)
Taking into account the molecular weights of isovaleric acid (102.13) and isobutyric acid (88.11), an EC50 of 59.4 mg/L for isovaleric acid can be calculated.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 59.4 mg/L
Additional information
For the toxicity assessment of isovaleric acid to aquatic invertebrates, valid data could not be identified. Data for isobutyric acid as supporting substance will be used based on following reasons.
Both acids are closely related. Their carbon chain differs only in one carbon atom. Physical and physico-chemical properties as well as chemical reactivity will be quite similar. Main structural feature is the carboxylic acid group, which will have a major impact on the effects of both substances in aquatic systems. Thus, it is justified to use isobutyric acid as supporting substance in the evaluation of the short-term toxicity of isovaleric acid to aquatic invertebrates.
Supporting substance isobutyric acid
BASF AG 1989
Isobutyric acid was tested on the waterflea Daphnia magna in a 48-h acute immobilization test similar to OECD TG 202 under static conditions at concentrations of 0 (water control), 15.625, 31.3, 62.5, 125, 250, and 500 mg/L. Immobilization and other toxic effects were observed 3, 6, 24, and 48 h after initiation of the test.
The 48-h EC50 was determined to be 51.25 mg/L (BASF AG, 1989).
Isovaleric acid: short-term toxicity to aquatic invertebrates
Taking into account the molecular weights of isovaleric acid (102.13) and isobutyric acid (88.11), an EC50 of 59.4 mg/L for isovaleric acid is calculated.
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