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EC number: 241-475-6 | CAS number: 17462-58-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline Study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 987
- Report date:
- 1987
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- no
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- sec-butyl chloroformate
- EC Number:
- 241-475-6
- EC Name:
- sec-butyl chloroformate
- Cas Number:
- 17462-58-7
- Molecular formula:
- C5H9ClO2
- IUPAC Name:
- butan-2-yl carbonochloridate
- Reference substance name:
- sec.- butylchloroformate
- IUPAC Name:
- sec.- butylchloroformate
- Reference substance name:
- 87/0122
- IUPAC Name:
- 87/0122
- Details on test material:
- - Name of test material (as cited in study report): sek.Butylchlorformiat ( sec-butyl carbonochloridic acid ester) - Physical state: clear liquid - Analytical purity: > 99 % - Expiration date of the lot/batch: not reported - Stability under test conditions: ca. 12 month- Storage condition of test material: ca. 5°C
Constituent 1
Constituent 2
Constituent 3
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS- Source: Dr. K. Thomae GmbH, Biberach, D- Age at study inition: 8-9 weeks- Weight at study initiation: males 275 +- 25.3 g; females 191 +- 12.5 g- Diet (e.g. ad libitum): KLIBA Labordiaet Ratte/Maus 24 343-4 10 mm Pellet, Klingentalmuehle AG, Kaiseraugst, CH- Water (e.g. ad libitum): tap waterENVIRONMENTAL CONDITIONS- Temperature (°C): 20 - 24- Humidity (%): 30 - 70- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: unchanged (no vehicle)
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION- Exposure apparatus: The vapour was produced by a constant infusion pump coupled with a glas evaporator with a thermostat.
- Analytical verification of test atmosphere concentrations:
- yes
- Remarks:
- determined by GC
- Duration of exposure:
- 4 h
- Concentrations:
- analytical: 0.44 mg/L; 2.33 mg/L nominal: 0.64 mg/L; 2.70 mg/L
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days- Frequency of observations and weighing: weighing was performed at the beginning of the study and on d 7 and d 14; observations were performed serveral times on the day of exposure and at least once per work day- Necropsy of survivors performed: yes
- Statistics:
- not required
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 0.44 - < 2.33 mg/L air
- Exp. duration:
- 4 h
- Mortality:
- All animals of the high dose group died within 24 h. No mortality observed in the low dose group.
- Clinical signs:
- other: In both groups: At the beginning, eyelid closure, squatting posture, accelerated respiration, followed by irregular/ intermittent respiration, reduced startle reaction, anemic.Additionally in the high dose group: aqueous eye and nose discharge, salivation
- Body weight:
- Mean body weight gain of the low dose group was slightly reduced in the first observation week, but comparable to the reported historical control data in the second week.
- Gross pathology:
- Died animals: lung edemaSacrificed animals: nothing abnormal found
Applicant's summary and conclusion
- Executive summary:
The study is conducted according to the OECD Guideline 403 and is reliable with out any restriction.
5 male and female Wistar rats were exposed to 0.44 and 2.33 mg/L sec.-Butylchloroformate for 4 h. No animal died at 44 mg/L. The acute LC50 of sec.-Butylchloroformate is > 0.44 and < 2.33 mg/L after inhalative exposure for 4 h. Squatting posture and irregular respiration were seen even in the low dose group, where no mortality appeared.
Conclusion:
According to the results of the present study, the test substance sec.-Butylchloroformate has to be regarded as toxic after single inhalative exposure (R 23 according to EU classification requirements; acute inhalative Cat. 2 according to GHS requirements).
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