Registration Dossier
Registration Dossier
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EC number: 609-724-7 | CAS number: 39605-45-3
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- chronic toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with generally accepted scientific standards and described in sufficient detail
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 2 000
- Report date:
- 2000
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EPA OPP 83-1 (Chronic Toxicity)
- GLP compliance:
- yes
- Limit test:
- no
Test material
- Reference substance name:
- Atrazine
- EC Number:
- 217-617-8
- EC Name:
- Atrazine
- Cas Number:
- 1912-24-9
- Molecular formula:
- C8H14ClN5
- IUPAC Name:
- 6-chloro-N-ethyl-N'-isopropyl-1,3,5-triazine-2,4-diamine
- Details on test material:
- - Purity: 97.7%
-Lot/Batch No. FL-850612
Constituent 1
Test animals
- Species:
- dog
- Strain:
- Beagle
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: feed
- Vehicle:
- not specified
- Duration of treatment / exposure:
- 52 weeks
- Frequency of treatment:
- continuously
Doses / concentrationsopen allclose all
- Dose / conc.:
- 15 ppm
- Remarks:
- equivalent to 0.375 mg/kg
- Dose / conc.:
- 150 ppm
- Remarks:
- equivalent to 3.75 mg/kg
- Dose / conc.:
- 1 000 ppm
- Control animals:
- yes, concurrent vehicle
Results and discussion
Results of examinations
- Details on results:
- Treatment with 1000 ppm atrazine resulted in significantly depressed body weight gain and reduced food consumption. A treatment related effect on the heart in high dose animals correlated with cardioelectrographic changes, ascites, irregular heart beat, dilatation of the heart, and myocardial degeneration.
Effect levels
- Dose descriptor:
- NOAEL
- Effect level:
- 3.75 mg/kg bw/day (actual dose received)
- Based on:
- test mat.
- Sex:
- male/female
- Basis for effect level:
- body weight and weight gain
- histopathology: non-neoplastic
Target system / organ toxicity
- Critical effects observed:
- no
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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