Registration Dossier
Registration Dossier
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EC number: 211-492-3 | CAS number: 652-67-5
Endpoint summary
Administrative data
Description of key information
Oral: LD50: > 2000 mg/kg bw for rat
Dermal: LD50: > 2000 mg/kg bw for rat
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Acute toxicity: via dermal route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Additional information
Two toxicological studies were performed with the registered substance, the first one follows both the OECD Guideline 420: acute oral toxicity - fixed dose method and OECD Guideline 401: acute oral toxicity while the second one follows the OECD Guideline 402: acute dermal toxicity, in a certified GLP lab. So the reliability of this data can be ranked as klimisch code 1: reliable without restrictions. On the basis of this analysis, those studies can be chosen as the key studies.
Justification for classification or non-classification
According to Official Journal of the European Union 1272/2008 (CLP) dated December 16th 2008, isosorbide is non-classified in the acute toxicity hazard categories.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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