Registration Dossier
Registration Dossier
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EC number: 242-354-0 | CAS number: 18472-51-0
Melting point / freezing point
Administrative data
Link to relevant study record(s)
- Endpoint:
- melting point/freezing point
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2002
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 102 (Melting point / Melting Range)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.1 (Melting / Freezing Temperature)
- Version / remarks:
- Cited as Directive 92/69/EEC, A.1
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Infracor Chemistry Services, Marl Germany
- Type of method:
- differential scanning calorimetry
- Key result
- Melting / freezing pt.:
- 53 °C
- Atm. press.:
- 1 017 hPa
- Decomposition:
- no
- Sublimation:
- no
- Conclusions:
- Chlorhexidine digluconate starts to melt at 53°C and to decompose at approximately 157°C.
Reference
The melting point was observed at 53.3 and 53.4 °C, resp. (extrapolated onset-temperature of the DSC-curve). The maximum of the melting peak was observed at 63 and 64 °C with a small "shoulder" at approx. 80 °C.
Description of key information
Chlorhexidine digluconate starts to melt at 53°C and to decompose at approximately 157°C.
Key value for chemical safety assessment
- Melting / freezing point at 101 325 Pa:
- 53 °C
Additional information
The melting point of Chlorhexidine digluconate has been determined in a study according to OECD 102.
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