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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
short-term repeated dose toxicity: oral
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: GLP Guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1987

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
OECD Guideline 407 (Repeated Dose 28-Day Oral Toxicity Study in Rodents)
Qualifier:
according to guideline
Guideline:
EU Method B.7 (Repeated Dose (28 Days) Toxicity (Oral))
GLP compliance:
yes
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
3,5-dichloro-2,4-difluorobenzoyl fluoride
EC Number:
401-800-6
EC Name:
3,5-dichloro-2,4-difluorobenzoyl fluoride
Cas Number:
101513-70-6
Molecular formula:
C7HCl2F3O
IUPAC Name:
3,5-dichloro-2,4-difluorobenzoyl fluoride

Test animals

Species:
rat
Strain:
Wistar
Sex:
male/female

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
olive oil

Results and discussion

Effect levels

open allclose all
Dose descriptor:
NOEL
Effect level:
2 other: mg/kg bw/day
Based on:
test mat.
Sex:
male/female
Basis for effect level:
other: Reported as "no-observable-effect-level"
Dose descriptor:
NOAEL
Effect level:
> 50 other: mg/kg bw/day
Based on:
test mat.
Sex:
male/female
Basis for effect level:
other: Reported as "no-toxic-effect-level"

Target system / organ toxicity

Critical effects observed:
not specified

Applicant's summary and conclusion